Enzyme Details

Enzyme (Recommended) Name	hydroxymethylglutaryl-CoA synthase
Alternative names	3-hydroxy-3-methylglutaryl coenzyme A synthetase acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating) 3-hydroxy-3-methylglutaryl CoA synthetase 3-hydroxy-3-methylglutaryl coenzyme A synthase 3-hydroxy-3-methylglutaryl-CoA synthase 3-hydroxy-3-methylglutaryl-coenzyme A synthase beta-hydroxy-beta-methylglutaryl-CoA synthase HMG-CoA synthase acetoacetyl coenzyme A transacetase hydroxymethylglutaryl coenzyme A synthase hydroxymethylglutaryl coenzyme A-condensing enzyme
EC Classification	2.3.3.10
Classification	Transferases Acyltransferases Acyl groups converted into alkyl on transfer
Catalyses reactions	H2O + Acetyl-CoA <-> Coenzyme A + Acetate Coenzyme A + 3-Hydroxy-3-methylglutaryl-CoA <-> H2O + Acetyl-CoA + Acetoacetyl-CoA H2O + Acetyl-CoA + S-(3-Oxobutyl)-CoA <-> Coenzyme A + S-(4-Carboxy-3-hydroxy-isoamyl)-CoA
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 2.3.3.10