Enzyme Details

Enzyme (Recommended) Name	2-isopropylmalate synthase
Alternative names	acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) 3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) alpha-isopropylmalate synthetase alpha-isopropylmalate synthase alpha-isopropylmalic synthetase isopropylmalate synthase isopropylmalate synthetase
EC Classification	2.3.3.13
Classification	Transferases Acyltransferases Acyl groups converted into alkyl on transfer
Catalyses reactions	H2O + Acetyl-CoA <-> Coenzyme A + Acetate Coenzyme A + (R)-2-Ethylmalate <-> H2O + Acetyl-CoA + 2-Oxobutyrate Coenzyme A + 2-Isopropylmalate <-> H2O + Acetyl-CoA + alpha-Ketovaline H2O + Propanoyl-CoA <-> Coenzyme A + Propanoate Pyruvate + H2O + Acetyl-CoA <-> Coenzyme A + D-Citramalate H2O + Crotonoyl-CoA <-> Coenzyme A + 2-Butenoate H2O + Acetyl-CoA + 2-Oxopentanoate <-> Coenzyme A + 2-Propylmalate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 2.3.3.13