Enzyme Details

Enzyme (Recommended) Name	homocitrate synthase
Alternative names	acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming) 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating) acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase homocitrate synthetase HCS
EC Classification	2.3.3.14
Classification	Transferases Acyltransferases Acyl groups converted into alkyl on transfer
Catalyses reactions	Coenzyme A + Citrate <-> H2O + Acetyl-CoA + Oxaloacetate Coenzyme A + Homocitrate <-> H2O + Acetyl-CoA + 2-Oxoglutarate H2O + Acetyl-CoA + 3-Oxoadipate <-> Coenzyme A + 3-Hydroxy-3-carboxymethyl adipic acid
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 2.3.3.14