Enzyme Details

Enzyme (Recommended) Name	GTP cyclohydrolase I
Alternative names	GTP 7,8-8,9-dihydrolase GTP cyclohydrolase guanosine triphosphate cyclohydrolase guanosine triphosphate 8-deformylase dihydroneopterin triphosphate synthase GTP 8-formylhydrolase
EC Classification	3.5.4.16
Classification	Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amidines
Catalyses reactions	H2O + GTP <-> Formamidopyrimidine nucleoside triphosphate H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine H2O + Formamidopyrimidine nucleoside triphosphate <-> Formate + 2,5-Diaminopyrimidine nucleoside triphosphate 2,5-Diaminopyrimidine nucleoside triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine H2O + GTP <-> Formate + 7,8-Dihydroneopterin 3'-triphosphate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 3.5.4.16