Enzyme Details

Enzyme (Recommended) Name	GTP cyclohydrolase II
Alternative names	GTP 7,8-8,9-dihydrolase (diphosphate-forming) guanosine triphosphate cyclohydrolase II GTP-8-formylhydrolase
EC Classification	3.5.4.25
Classification	Hydrolases Acting on carbon-nitrogen bonds, other than peptide bonds In cyclic amidines
Catalyses reactions	3 H2O + GTP <-> Diphosphate + Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine H2O + GTP <-> Diphosphate + GMP 2 H2O + Formamidopyrimidine nucleoside triphosphate <-> Diphosphate + Formate + 2,5-Diamino-6-hydroxy-4-(5'-phosphoribosylamino)-pyrimidine
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 3.5.4.25