Enzyme Details

Enzyme (Recommended) Name	steroid Delta-isomerase
Alternative names	3-oxosteroid Delta5-Delta4-isomerase hydroxysteroid isomerase steroid isomerase Delta5-ketosteroid isomerase Delta5(or Delta4)-3-keto steroid isomerase Delta5-steroid isomerase 3-oxosteroid isomerase Delta5-3-keto steroid isomerase Delta5-3-oxosteroid isomerase
EC Classification	5.3.3.1
Classification	Isomerases Intramolecular oxidoreductases Transposing C=C Bonds
Catalyses reactions	NAD+ + 3beta-Hydroxyandrost-5-en-17-one <-> NADH + H+ + Androst-4-ene-3,17-dione NADP+ + 3beta-Hydroxyandrost-5-en-17-one <-> H+ + NADPH + Androst-4-ene-3,17-dione NAD+ + Pregnenolone <-> NADH + H+ + Progesterone NADP+ + Pregnenolone <-> H+ + NADPH + Progesterone NADH + H+ + Testosterone <-> NAD+ + Androst-5-ene-3beta,17beta-diol 3-Oxo-delta5-steroid <-> 3-Oxo-delta4-steroid NADH + H+ + Cortisol <-> NAD+ + 11beta,17alpha,21-Trihydroxypregnenolone H+ + NADPH + Cortisol <-> NADP+ + 11beta,17alpha,21-Trihydroxypregnenolone NAD+ + 17alpha-Hydroxypregnenolone <-> NADH + H+ + 17alpha-Hydroxyprogesterone NADP+ + 17alpha-Hydroxypregnenolone <-> H+ + NADPH + 17alpha-Hydroxyprogesterone NAD+ + 21-Hydroxypregnenolone <-> NADH + H+ + 11-Deoxycorticosterone NADP+ + 21-Hydroxypregnenolone <-> H+ + NADPH + 11-Deoxycorticosterone NADH + H+ + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NAD+ + 16alpha-Hydroxydehydroepiandrosterone H+ + NADPH + 16alpha-Hydroxyandrost-4-ene-3,17-dione <-> NADP+ + 16alpha-Hydroxydehydroepiandrosterone NADH + H+ + 11-Deoxycortisol <-> NAD+ + 17alpha,21-Dihydroxypregnenolone H+ + NADPH + 11-Deoxycortisol <-> NADP+ + 17alpha,21-Dihydroxypregnenolone Androst-5-ene-3,17-dione <-> Androst-4-ene-3,17-dione
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 5.3.3.1