Enzyme Details

Enzyme (Recommended) Name	prostaglandin-I synthase
Alternative names	(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase prostacyclin synthase prostacycline synthetase prostagladin I2 synthetase PGI2 synthase PGI2 synthetase
EC Classification	5.3.99.4
Classification	Isomerases Intramolecular oxidoreductases Other intramolecular oxidoreductases
Catalyses reactions	Prostaglandin H2 <-> Prostaglandin I2 Prostaglandin H1 <-> Malondialdehyde + 12-Hydroxy-8,10-heptadecadienoic acid Prostaglandin H2 <-> Prostaglandin D2 Carbon monoxide + reduced PGIS <-> Enzyme-ligand complex 10-Hydroperoxyoctadeca-8,12-dienoic acid <-> Unknown + 10-Oxodec-8-enoic acid Imidazole + PGIS <-> Enzyme-ligand complex PGIS + 4-Phenylimidazole <-> Enzyme-ligand complex 1-Phenylimidazole + PGIS <-> Enzyme-ligand complex PGIS + 1-Benzylimidazole <-> Enzyme-ligand complex Clotrimazole + PGIS <-> Enzyme-ligand complex Minoxidil + PGIS <-> Enzyme-ligand complex Prostaglandin H2 + PGIS <-> Enzyme-ligand complex PGIS + Sodium cyanide <-> Enzyme-ligand complex Pyridine + PGIS <-> Enzyme-ligand complex
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 5.3.99.4