Enzyme Details

Enzyme (Recommended) Name	UDP-N-acetylmuramoyl-tripeptide---D-alanyl-D-alanine ligase
Alternative names	UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine:D-alanyl-D-alanine ligase (ADP-forming) MurF synthetase UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase uridine diphosphoacetylmuramoylpentapeptide synthetase UDPacetylmuramoylpentapeptide synthetase UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase
EC Classification	6.3.2.10
Classification	Ligases Forming carbon-nitrogen bonds Acid--amino-acid ligases (peptide synthases)
Catalyses reactions	ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <-> ADP + Phosphate + UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine ATP + D-Alanyl-D-phenylalanine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-phenylalanine ATP + D-Alanyl-D-lactate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-lactate ATP + D-Alanyl-D-2-hydroxybutanoate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-2-hydroxybutanoate ATP + D-Alanyl-D-methionine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-methionine
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 6.3.2.10