Enzyme Details

Enzyme (Recommended) Name	dihydrofolate synthase
Alternative names	7,8-dihydropteroate:L-glutamate ligase (ADP-forming) dihydrofolate synthetase 7,8-dihydrofolate synthetase H2-folate synthetase 7,8-dihydropteroate:L-glutamate ligase (ADP) dihydrofolate synthetase-folylpolyglutamate synthetase folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase FHFS FHFS/FPGS dihydropteroate:L-glutamate ligase (ADP-forming) DHFS
EC Classification	6.3.2.12
Classification	Ligases Forming carbon-nitrogen bonds Acid--amino-acid ligases (peptide synthases)
Catalyses reactions	ATP + L-Glutamate + 10-Formyltetrahydrofolate <-> ADP + Phosphate + 10-Formyltetrahydrofolyl L-glutamate ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 6.3.2.12