Pathway Details
Recommended name
Biosynthesis of vancomycin group antibiotics
Alternative names
Reactions
dTDPglucose <-> H2O + dTDP-4-dehydro-6-deoxy-D-glucose
4,6-Dideoxy-4-oxo-dTDP-D-glucose <-> H2O + dTDP 1-ester with (6R)-5,6-dihydro-4-hydroxy-6-methyl-5-oxo-2H-pyran
dTDPglucose <-> H2O + 4,6-Dideoxy-4-oxo-dTDP-D-glucose
O2 + 3,5-Dihydroxyphenylacetyl-CoA <-> Coenzyme A + 3,5-Dihydroxyphenylglyoxylate
3 Malonyl-CoA <-> H2O + 3,5-Dihydroxyphenylacetyl-CoA
L-Tyrosine + 4-Hydroxyphenylglyoxylate <-> 3-(4-Hydroxyphenyl)pyruvate + L-4-Hydroxyphenylglycine
S-Adenosyl-L-methionine + dTDP-3-amino-2,3,6-trideoxy-D-threo-hexopyranos-4-ulose <-> S-Adenosyl-L-homocysteine + dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose <-> dTDP-L-4-oxovancosamine
H+ + NADPH + dTDP-L-4-oxovancosamine <-> NADP+ + dTDP-L-epivancosamine
dTDP-L-4-oxovancosamine <-> dTDP-L-vancosamine
Pyridoxamine phosphate + dTDP 1-ester with (6R)-5,6-dihydro-4-hydroxy-6-methyl-5-oxo-2H-pyran <-> Pyridoxal phosphate + dTDP-3-amino-2,3,6-trideoxy-D-threo-hexopyranos-4-ulose
3-(4-Hydroxyphenyl)pyruvate <-> CO2 + (S)-4-Hydroxymandelate
Riboflavin-5-phosphate + (S)-4-Hydroxymandelate <-> Reduced FMN + 4-Hydroxyphenylglyoxylate
Pyridoxamine phosphate + 3,5-Dihydroxyphenylglyoxylate <-> Pyridoxal phosphate + 3,5-Dihydroxy-phenylglycine
dTDP-D-glucose <-> H2O + dTDP-4-dehydro-6-deoxy-D-glucose
dTDP-D-glucose <-> H2O + 4,6-Dideoxy-4-oxo-dTDP-D-glucose
Classification
Metabolism of Terpenoids and Polyketides
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