Pathway Details
Recommended name
Novobiocin biosynthesis
Alternative names
Reactions
L-Tyrosine + 2-Oxoglutarate <-> L-Glutamate + 3-(4-Hydroxyphenyl)pyruvate
NAD+ + Prephenate <-> NADH + H+ + CO2 + 3-(4-Hydroxyphenyl)pyruvate
ATP + L-Proline <-> Diphosphate + AMP + L-Prolyl-[pcp]
FAD + L-Prolyl-[pcp] <-> FADH2 + 2-Pyrroline-2-carboxyl-[pcp]
2-Pyrroline-2-carboxyl-[pcp] <-> Pyrrole-2-carboxyl-[pcp]
S-Adenosyl-L-methionine + Pyrrole-2-carboxyl-[pcp] <-> S-Adenosyl-L-homocysteine + 5-Methyl-pyrrole-2-carboxyl-[pcp]
S-Adenosyl-L-methionine + dTDP-L-rhamnose <-> S-Adenosyl-L-homocysteine + dTDP-5-dimethyl-L-lyxose
ATP + L-Tyrosine <-> Diphosphate + AMP + L-Tyrosyl-[pcp]
O2 + L-Tyrosyl-[pcp] <-> H2O + beta-Hydroxy-L-tyrosyl-[pcp]
beta-Hydroxy-L-tyrosyl-[pcp] <-> beta-Keto-L-tyrosyl-[pcp]
S-Adenosyl-L-methionine + beta-Keto-L-tyrosyl-[pcp] <-> S-Adenosyl-L-homocysteine + 3-Methyl-beta-keto-L-tyrosyl-[pcp]
3-Methyl-beta-keto-L-tyrosyl-[pcp] <-> 2-Hydroxy-3-methyl-beta-keto-L-tyrosyl-[pcp]
2-Hydroxy-3-methyl-beta-keto-L-tyrosyl-[pcp] <-> 3-Amino-4,7-dihydroxy-8-methylcoumarin
Dimethylallyl diphosphate + 3-(4-Hydroxyphenyl)pyruvate <-> Diphosphate + 3-Dimethylallyl-4-hydroxyphenylpyruvate
O2 + 3-Dimethylallyl-4-hydroxyphenylpyruvate <-> CO2 + 3-Dimethylallyl-4-hydroxymandelic acid
O2 + 3-Dimethylallyl-4-hydroxymandelic acid <-> CO2 + 3-Dimethylallyl-4-hydroxybenzoate
beta-Hydroxy-L-tyrosyl-[pcp] <-> 3-Dimethylallyl-beta-hydroxy-L-tyrosyl-[pcp]
3-Dimethylallyl-beta-hydroxy-L-tyrosyl-[pcp] <-> 3-Dimethylallyl-4-hydroxybenzaldehyde
3-Dimethylallyl-4-hydroxyphenylpyruvate <-> 3-Dimethylallyl-4-hydroxybenzaldehyde
3-Dimethylallyl-4-hydroxybenzaldehyde <-> 3-Dimethylallyl-4-hydroxybenzoate
beta-Keto-L-tyrosyl-[pcp] <-> 2-Hydroxy-beta-keto-L-tyrosyl-[pcp]
2-Hydroxy-beta-keto-L-tyrosyl-[pcp] <-> 3-Amino-4,7-dihydroxycoumarin
3-Amino-4,7-dihydroxycoumarin <-> 3-Amino-4,7-dihydroxy-8-chlorocoumarin
2 S-Adenosyl-L-methionine + Coumermic acid + dTDP-5-dimethyl-L-lyxose <-> 2 S-Adenosyl-L-homocysteine + 2 dTDP + Coumermycin D
Coumermycin D + 2 5-Methyl-pyrrole-2-carboxyl-[pcp] <-> Coumermycin A1
ATP + 3-Dimethylallyl-4-hydroxybenzoate + 3-Amino-4,7-dihydroxy-8-methylcoumarin <-> Diphosphate + AMP + Novobiocic acid
Novobiocic acid + dTDP-5-dimethyl-L-lyxose <-> dTDP + Desmethyldescarbamoylnovobiocin
S-Adenosyl-L-methionine + Desmethyldescarbamoylnovobiocin <-> S-Adenosyl-L-homocysteine + Descarbamoylnovobiocin
Carbamoyl phosphate + Descarbamoylnovobiocin <-> Phosphate + Novobiocin
Clorobiocic acid + dTDP-5-dimethyl-L-lyxose <-> dTDP + Novclobiocin 105
S-Adenosyl-L-methionine + Novclobiocin 105 <-> S-Adenosyl-L-homocysteine + Novclobiocin 104
Novclobiocin 104 + 5-Methyl-pyrrole-2-carboxyl-[pcp] <-> Clorobiocin
3-Dimethylallyl-4-hydroxybenzoate + 3-Amino-4,7-dihydroxy-8-chlorocoumarin <-> Clorobiocic acid
ATP + 3-Amino-4,7-dihydroxy-8-methylcoumarin + 3-Methylpyrrole-2,4-dicarboxylic acid <-> Diphosphate + AMP + Coumeroic acid
ATP + 3-Amino-4,7-dihydroxy-8-methylcoumarin + Coumeroic acid <-> Diphosphate + AMP + Coumermic acid
ATP + 3-Amino-4,7-dihydroxy-8-methylcoumarin + 3-Methyl-4-hydroxybenzoate <-> Diphosphate + AMP + Novobiocic acid analog
Novobiocic acid + dTDP-L-noviose <-> dTDP + Desmethyldescarbamoylnovobiocin
Novobiocic acid analog + dTDP-L-noviose <-> dTDP + Desmethyl descarbamoyl novobiocin analog
Classification
Biosynthesis of Other Secondary Metabolites
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