Pathway Details

Recommended name

JAK-STAT signaling pathway

Alternative names

Reactions

Ciliary neurotrophic factor receptor alpha + JAK-1 <-> Receptor JAK complex

Receptor JAK complex + Interferon alpha-1 <-> IFNRJ

2 IFNRJ <-> IFNRJ2

IFNRJ2 <-> IFNRJ2_activated

STAT1 + IFNRJ2_activated <-> ((IFNRJ2_activated)(STAT1))

((IFNRJ2_activated)(STAT1)) <-> STAT1_activated + IFNRJ2_activated

STAT1_activated + IFNRJ2_activated <-> IFNRJ2_activatedSTAT1_activated

2 STAT1_activated <-> ((STAT1_activated)(STAT1_activated))

SHP2 + IFNRJ2_activated <-> ((IFNRJ2_activated)(SHP2))

((IFNRJ2_activated)(SHP2)) <-> IFNRJ2 + SHP2

STAT1_activated + Phosphatase <-> ((STAT1_activated)(PP))

((STAT1_activated)(PP)) <-> STAT1 + Phosphatase

((STAT1_activated)(STAT1_activated)) + Phosphatase <-> ((STAT1_activated)(STAT1_activated)(PP))

((STAT1_activated)(STAT1_activated)(PP)) <-> ((STAT1)(STAT1_activated)) + Phosphatase

STAT1 + STAT1_activated <-> ((STAT1)(STAT1_activated))

((STAT1_activated)(STAT1_activated)) <-> ((STAT1_activated)(STAT1_activated))

STAT1 <-> STAT1

pool <-> ((STAT1_activated)(STAT1_activated)) + mRNA

SOCS1 + IFNRJ2_activated <-> ((IFNRJ2_activated)(SOCS1))

STAT1 + ((IFNRJ2_activated)(SOCS1)) <-> ((IFNRJ2_activated)(SOCS1)(STAT1))

SHP2 + ((IFNRJ2_activated)(SOCS1)(STAT1)) <-> ((IFNRJ2_activated)(SHP2)(SOCS1)(STAT1))

((IFNRJ2_activated)(SHP2)(SOCS1)(STAT1)) <-> STAT1 + SHP2 + SOCS1 + IFNRJ2_activated

((IFNRJ2_activated)(SHP2)(SOCS1)(STAT1)) <-> SOCS1 + ((IFNRJ2_activated)(SHP2)(STAT1))

Classification

Signal Transduction

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