Pathway Details

Recommended name

Penicillin and cephalosporin biosynthesis

Alternative names

Reactions

H2O + Penicillin <-> Carboxylate + 6-Aminopenicillanate

H2O + Cephalosporin C <-> Acetate + Deacetylcephalosporin C

Coenzyme A + Cephalosporin C <-> Acetyl-CoA + Deacetylcephalosporin C

Isopenicillin N <-> Penicillin N

H2O + Penicillin G <-> Substituted beta-amino acid

3 ATP + L-Valine + L-Cysteine + L-2-Aminoadipate <-> 3 Diphosphate + 3 AMP + delta(L-2-Aminoadipyl)-L-cysteinyl-D-valine

O2 + delta(L-2-Aminoadipyl)-L-cysteinyl-D-valine <-> 2 H2O + Isopenicillin N

H2O + 2 CO2 + 2 Succinate + Deacetylcephalosporin C <-> 2 O2 + 2 2-Oxoglutarate + Penicillin N

H2O + CO2 + Succinate + Deacetylcephalosporin C <-> O2 + 2-Oxoglutarate + Deacetoxycephalosporin C

Carbamoyl phosphate + Deacetylcephalosporin C <-> Phosphate + O-Carbamoyl-deacetylcephalosporin C

O2 + 2-Oxoglutarate + Penicillin N <-> H2O + CO2 + Succinate + Deacetoxycephalosporin C

O2 + 2-Oxoglutarate + O-Carbamoyl-deacetylcephalosporin C <-> H2O + CO2 + Succinate + 7a-Hydroxy-o-carbamoyl-deacetylcephalosporin C

S-Adenosyl-L-homocysteine + Cephamycin C <-> S-Adenosyl-L-methionine + 7a-Hydroxy-o-carbamoyl-deacetylcephalosporin C

H2O + Acyl-CoA + Isopenicillin N <-> Coenzyme A + Penicillin + L-2-Aminoadipate

H2O + Penicillin <-> Penicilloic acid

H2O + Cephalothin <-> Substituted beta-amino acid

H2O + Nitrocefin <-> Substituted beta-amino acid

H2O + Oxacillin <-> Substituted beta-amino acid

H2O + Cloxacillin <-> Substituted beta-amino acid

H2O + Carbenicillin <-> Substituted beta-amino acid

H2O + Bocillin FL <-> Substituted beta-amino acid

H2O + Ampicillin <-> Substituted beta-amino acid

H2O + 6-beta-Hydroxymethylpenicillanate <-> Substituted beta-amino acid

H2O + 6-beta-(1-Hydroxyethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-beta-(1-Hydroxy-1-methylethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-Hydroxymethylpenicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-(1-Hydroxyethyl)-penicillanate <-> Substituted beta-amino acid

H2O + 6-alpha-(1-Hydroxy-1-methylethyl)-penicillanate <-> Substituted beta-amino acid

H2O + Cephalosporin <-> Substituted beta-amino acid

H2O + Cefuroxime <-> Substituted beta-amino acid

H2O + Cefotaxime <-> Substituted beta-amino acid

H2O + 3-[2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetylglycyl]oxybenzoic acid <-> 3-Hydroxybenzoate + 2-(2-Aminothiazol-4-yl)-2-(Z)-methoxyiminoacetylglycine

H2O + 3-[(Phenylacetyl)glycyl]oxybenzoic acid <-> 3-Hydroxybenzoate + Phenylacetylglycine

O2 + 2-Oxoglutarate + Penicillin G <-> H2O + CO2 + Succinate + Phenylacetyl-7-aminodeacetoxy cephalosporanic acid

H2O + Cephaloridine <-> Substituted beta-amino acid

H2O + Piperacillin <-> Substituted beta-amino acid

H2O + Cefaclor <-> Substituted beta-amino acid

H2O + O2 + Cephalosporin C <-> NH3 + H2O2 + 7-(5-Carboxyl-5-oxopentanyl)-aminocephalosporinate

H2O + (7R)-7-(4-Carboxybutanamido)cephalosporanate <-> Glutarate + 7-Aminocephalosporanic acid

H2O + Methicillin <-> Substituted beta-amino acid

H2O + Mecillinam <-> Substituted beta-amino acid

H2O + Loracarbef <-> Substituted beta-amino acid

H2O + Amoxicillin <-> Substituted beta-amino acid

H2O + Cephalosporin C <-> Substituted beta-amino acid

Classification

Biosynthesis of Other Secondary Metabolites

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