Pathway Details

Recommended name

Ubiquinone and other terpenoid-quinone biosynthesis

Alternative names

Reactions

S-Adenosyl-L-methionine + 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone <-> S-Adenosyl-L-homocysteine + Ubiquinone

Ubiquinol <-> 2 H+ + Ubiquinone

H2O + 4-Hydroxybenzoyl-CoA <-> Coenzyme A + 4-Hydroxybenzoate

trans,trans-Farnesyl diphosphate <-> Diphosphate + (+)-delta-Cadinene

beta-Carotene <-> Zeaxanthin

Dimethylallyl diphosphate + Tryptophan <-> Diphosphate + Dimethylallyltryptophan

4-Hydroxybenzoate + UDPglucose <-> UDP + 4-(beta-D-glucosyloxy)benzoate

H2O + Oxidized dithiothreitol + Phylloquinone <-> 1,4-Dithiothreitol + Vitamin K epoxide

S-Adenosyl-L-methionine + 2-Octaprenyl-6-hydroxyphenol <-> S-Adenosyl-L-homocysteine + 2-Octaprenyl-6-methoxyphenol

2-Oxoglutarate + Isochorismate <-> CO2 + 5-Enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate

H2O + 2-Succinylbenzoate <-> 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate

Isopentenyl diphosphate + trans,trans-Farnesyl diphosphate <-> Diphosphate + Geranylgeranyl diphosphate

Diphosphate + Trichodiene <-> Nerolidyl diphosphate

all-trans-Nonaprenyl diphosphate + 4-Hydroxybenzoate <-> Diphosphate + Nonaprenyl-4-hydroxybenzoate

Geranyl diphosphate <-> Diphosphate + Terpinolene

Squalene <-> Hopanoid

H+ + NADPH + O2 + 6-Oxocineole <-> H2O + NADP+ + 1,6,6-Trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one

NAD+ + 3-(4-Hydroxyphenyl)lactate <-> NADH + H+ + 3-(4-Hydroxyphenyl)pyruvate

Isopentenyl diphosphate + trans,trans-Farnesyl diphosphate <-> Diphosphate + trans,trans,cis-Geranylgeranyl diphosphate

Iridodial <-> Iridotrial

4-Hydroxybenzoate + Geranyl diphosphate <-> Diphosphate + 3-Geranyl-4-hydroxybenzoate

H+ + NADPH + O2 + 2-Octaprenyl-6-methoxyphenol <-> H2O + NADP+ + 2-Octaprenyl-6-methoxy-1,4-benzoquinone

UDP-D-glucose + 4-Hydroxybenzoate <-> UDP + 4-(beta-D-glucosyloxy)benzoate

Dimethylallyl diphosphate + Isopentenyl diphosphate <-> Diphosphate + Geranyl diphosphate

H2O + Squalene <-> Diplopterol

H+ + NADPH + 2 trans,trans-Farnesyl diphosphate <-> NADP+ + 2 Diphosphate + Squalene

Geranyl diphosphate <-> Iridodial

1,4-Dihydroxy-2-naphthoate + all-trans-Octaprenyl diphosphate <-> CO2 + Diphosphate + 2-Demethylmenaquinone

S-Adenosyl-L-methionine + 2-Hexaprenyl-6-methoxy-1,4-benzoquinone <-> S-Adenosyl-L-homocysteine + 2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone

2-Succinylbenzoyl-CoA <-> Coenzyme A + 1,4-Dihydroxy-2-naphthoate

Pyruvate + 4-Hydroxybenzoate <-> Chorismate

Isopentenyl diphosphate <-> Dimethylallyl diphosphate

S-Adenosyl-L-methionine + 2-Demethylmenaquinone <-> S-Adenosyl-L-homocysteine + Menaquinone

3-Octaprenyl-4-hydroxybenzoate <-> CO2 + 2-Octaprenylphenol

2 Geranylgeranyl diphosphate <-> H+ + Diphosphate + Prephytoene diphosphate

NADP+ + (R)-3-(4-Hydroxyphenyl)lactate <-> H+ + NADPH + 3-(4-Hydroxyphenyl)pyruvate

2-Succinylbenzoate <-> OH- + Spirodilactone

S-Adenosyl-L-homocysteine + Ubiquinone <-> S-Adenosyl-L-methionine + 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

O2 + 3-(4-Hydroxyphenyl)pyruvate <-> CO2 + Homogentisate

(S)-2,3-Epoxysqualene <-> Triterpenoid

H+ + NADPH + O2 + trans-Cinnamate <-> H2O + NADP+ + 4-Coumarate

H2O + Squalene <-> Tetrahymanol

2-Polyprenylphenol <-> 4-Hydroxy-3-polyprenylbenzoate

ATP + Coenzyme A + 4-Coumarate <-> Diphosphate + AMP + 4-Coumaroyl-CoA

H2O + 3-alpha(S)-Strictosidine <-> Tryptamine + Secologanin

Isopentenyl diphosphate + Geranyl diphosphate <-> Diphosphate + trans,trans-Farnesyl diphosphate

Acceptor + beta-Carotene <-> Reduced acceptor + Lycopene

2-Succinylbenzoyl-CoA <-> H2O + 1,4-Dihydroxy-2-naphthoyl-CoA

Dimethylallyltryptophan <-> Elymoclavine

3-alpha(S)-Strictosidine <-> Indole alkaloid

NAD+ + 6-endo-Hydroxycineole <-> NADH + H+ + 6-Oxocineole

2 5-Hydroxy-2-polyprenylphenol <-> O2 + 2 2-Polyprenylphenol

trans,trans-Farnesyl diphosphate <-> Diphosphate + Aristolochene

trans,trans-Farnesyl diphosphate <-> Polyprenol

H2O + 1,4-Dihydroxy-2-naphthoyl-CoA <-> Coenzyme A + 1,4-Dihydroxy-2-naphthoate

H+ + NADPH + O2 + Deoxyloganin <-> H2O + NADP+ + Loganin

ATP + Coenzyme A + 2-Succinylbenzoate <-> Diphosphate + AMP + 2-Succinylbenzoyl-CoA

Phytoene <-> Hydrogen + Phytofluene

Pimaradiene <-> Abietate

Acceptor + zeta-Carotene <-> Reduced acceptor + Lycopene

O2 + 3-Hexaprenyl-4-hydroxybenzoate <-> 3-Hexaprenyl-4,5-dihydroxybenzoate

H+ + NADPH + Ubiquinone-10 <-> NADP+ + Ubiquinol

L-Tyrosine + 2-Oxoglutarate <-> L-Glutamate + 3-(4-Hydroxyphenyl)pyruvate

2-Succinylbenzoyl-CoA <-> Coenzyme A + Spirodilactone

3 S-Adenosyl-L-homocysteine + Ubiquinol <-> O2 + 3 S-Adenosyl-L-methionine + 5-Hydroxy-2-polyprenylphenol

S-Adenosyl-L-methionine + 3-Demethylubiquinone-9 <-> S-Adenosyl-L-homocysteine + Ubiquinone-9

S-Adenosyl-L-methionine + gamma-Tocopherol <-> S-Adenosyl-L-homocysteine + alpha-Tocopherol

Squalene <-> Diploptene

S-Adenosyl-L-methionine + 2-Octaprenyl-6-methoxy-1,4-benzoquinone <-> S-Adenosyl-L-homocysteine + 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone

H2O + 1,6,6-Trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one <-> 4,5-Dihydro-5,5-dimethyl-4-(3-oxobutyl)furan-2(3H)-onehexanoate

H+ + NADPH + O2 + 2-Hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone <-> H2O + NADP+ + 2-Hexaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

4-Hydroxybenzoate + all-trans-Hexaprenyl diphosphate <-> Diphosphate + 3-Hexaprenyl-4-hydroxybenzoate

4-Hydroxybenzoate + n Polyisopentenylpyrophosphate <-> n Diphosphate + 4-Hydroxy-3-polyprenylbenzoate

NAD+ + (R)-3-(4-Hydroxyphenyl)lactate <-> NADH + H+ + 3-(4-Hydroxyphenyl)pyruvate

trans,trans-Farnesyl diphosphate <-> Diphosphate + Vetispiradiene

Iridotrial <-> Deoxyloganin

Phytyl diphosphate + 1,4-Dihydroxy-2-naphthoate <-> CO2 + Diphosphate + 2-Phytyl-1,4-naphthoquinone

2-Oxoglutarate + Isochorismate <-> Pyruvate + CO2 + 2-Succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate

7 Isopentenyl diphosphate + trans,trans,cis-Geranylgeranyl diphosphate <-> 7 Diphosphate + di-trans,poly-cis-Undecaprenyl diphosphate

H+ + NADPH + O2 + 2-Octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone <-> H2O + NADP+ + 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone

Trichodiene <-> Nivalenol

trans,trans-Farnesyl diphosphate <-> Nerolidyl diphosphate

Sterol <-> (S)-2,3-Epoxysqualene

S-Adenosyl-L-methionine + 2-Phytyl-1,4-naphthoquinone <-> S-Adenosyl-L-homocysteine + Phylloquinone

H+ + NADPH + O2 + 2-Octaprenylphenol <-> H2O + NADP+ + 2-Octaprenyl-6-hydroxyphenol

3-Hexaprenyl-4-hydroxy-5-methoxybenzoate <-> CO2 + 2-Hexaprenyl-6-methoxyphenol

O2 + Reduced acceptor + Squalene <-> H2O + Acceptor + (S)-2,3-Epoxysqualene

4-Hydroxybenzoate + all-trans-Octaprenyl diphosphate <-> Diphosphate + 3-Octaprenyl-4-hydroxybenzoate

S-Adenosyl-L-methionine + 3-Hexaprenyl-4,5-dihydroxybenzoate <-> S-Adenosyl-L-homocysteine + 3-Hexaprenyl-4-hydroxy-5-methoxybenzoate

H+ + NADPH + O2 + Loganin <-> 2 H2O + NADP+ + Secologanin

Aristolochene <-> PR-toxin

trans,trans-Farnesyl diphosphate <-> Diphosphate + Abscisate

O2 + 2-Hexaprenyl-6-methoxyphenol <-> H2O + 2-Hexaprenyl-6-methoxy-1,4-benzoquinone

Chorismate <-> Isochorismate

Classification

Metabolism of Cofactors and Vitamins