Pathway Details

Recommended name

Toluene degradation

Alternative names

Reactions

Succinate + Acceptor <-> Fumarate + Reduced acceptor

Pyruvate + Acetaldehyde <-> 4-Hydroxy-2-oxopentanoate

NAD+ + H2O + 4-Hydroxybenzaldehyde <-> NADH + H+ + 4-Hydroxybenzoate

H2O + NADP+ + 4-Hydroxybenzaldehyde <-> H+ + NADPH + 4-Hydroxybenzoate

NAD+ + H2O + Benzaldehyde <-> NADH + H+ + Benzoate

H2O + NADP+ + Benzaldehyde <-> H+ + NADPH + Benzoate

NAD+ + Benzyl alcohol <-> NADH + H+ + Benzaldehyde

NAD+ + H2O + Benzyl alcohol <-> NADH + H+ + O2 + Toluene

H2O + 2-Hydroxy-2,4-pentadienoate <-> 4-Hydroxy-2-oxopentanoate

O2 + Ferredoxin + 4-Cresol <-> H2O + Oxidized ferredoxin + 4-Hydroxybenzaldehyde

NADH + H+ + O2 + Toluene <-> NAD+ + Toluene-cis-dihydrodiol

H+ + NADPH + O2 + Toluene <-> H2O + NADP+ + o-Cresol

H+ + NADPH + O2 + Toluene <-> H2O + NADP+ + 3-Cresol

H+ + NADPH + O2 + 3-Cresol <-> H2O + NADP+ + 2,3-Dihydroxytoluene

H2O + Oxidized ferredoxin + 4-Cresol <-> O2 + Ferredoxin + Toluene

H+ + NADPH + O2 + o-Cresol <-> H2O + NADP+ + 2,3-Dihydroxytoluene

NAD+ + Toluene-cis-dihydrodiol <-> NADH + H+ + 2,3-Dihydroxytoluene

O2 + 2,3-Dihydroxytoluene <-> 2-Hydroxy-6-keto-2,4-heptadienoate

NADP+ + 3-Hydroxybenzyl alcohol <-> H+ + NADPH + 3-Hydroxybenzaldehyde

4-Carboxymethyl-4-methylbut-2-en-1,4-olide <-> 4-Carboxymethyl-3-methylbut-2-en-1,4-olide

Acetate + 2-Hydroxy-2,4-pentadienoate <-> H2O + 2-Hydroxy-6-keto-2,4-heptadienoate

NAD+ + 4-Sulfobenzyl alcohol <-> NADH + H+ + 4-Sulfobenzaldehyde

NAD+ + H2O + 4-Sulfobenzaldehyde <-> NADH + H+ + 4-Sulfobenzoate

NAD+ + alpha-Hydroxy-p-xylene <-> NADH + H+ + p-Tolualdehyde

NADH + H+ + O2 + p-Xylene <-> NAD+ + H2O + alpha-Hydroxy-p-xylene

H2O + NADP+ + p-Tolualdehyde <-> H+ + NADPH + Toluate

NADH + H+ + O2 + Toluate <-> NAD+ + cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate

H+ + NADPH + O2 + Toluate <-> NADP+ + cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate

NAD+ + cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <-> NADH + H+ + CO2 + 4-Methylcatechol

NADP+ + cis-1,2-Dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate <-> H+ + NADPH + CO2 + 4-Methylcatechol

NADH + H+ + O2 + Toluene-4-sulfonate <-> NAD+ + 4-Methylcatechol + HSO3-

O2 + 4-Methylcatechol <-> 2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde

Pyruvate + Propanal <-> 4-Hydroxy-2-oxohexanoate

O2 + 4-Methylcatechol <-> 3-Methyl-cis,cis-hexadienedioate

4-Carboxymethyl-4-methylbut-2-en-1,4-olide <-> 3-Methyl-cis,cis-hexadienedioate

NAD+ + 1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate <-> NADH + H+ + CO2 + 2,3-Dihydroxytoluene

NAD+ + 1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate <-> NADH + H+ + CO2 + 2,3-Dihydroxytoluene

NAD+ + 3-Methylbenzyl alcohol <-> NADH + H+ + 3-Methylbenzaldehyde

NAD+ + 2-Methylbenzyl alcohol <-> NADH + H+ + 2-Methylbenzaldehyde

NAD+ + H2O + 2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde <-> NADH + H+ + 2-Hydroxy-5-methyl-cis,cis-muconate

2-Oxo-5-methyl-cis-muconate <-> CO2 + 2-Hydroxy-cis-hex-2,4-dienoate

2-Hydroxy-5-methyl-cis,cis-muconate <-> 2-Oxo-5-methyl-cis-muconate

NADH + H+ + O2 + o-Toluate <-> NAD+ + 1,2-Dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate

NADH + H+ + O2 + o-Xylene <-> NAD+ + H2O + 2-Methylbenzyl alcohol

NADH + H+ + O2 + m-Xylene <-> NAD+ + H2O + 3-Methylbenzyl alcohol

O2 + Reduced rubredoxin + o-Xylene <-> H2O + Oxidized rubredoxin + 2-Methylbenzyl alcohol

O2 + Reduced rubredoxin + p-Xylene <-> H2O + Oxidized rubredoxin + alpha-Hydroxy-p-xylene

O2 + Reduced rubredoxin + m-Xylene <-> H2O + Oxidized rubredoxin + 3-Methylbenzyl alcohol

NAD+ + (Hydroxymethylphenyl)succinyl-CoA <-> NADH + H+ + Benzoylsuccinyl-CoA

Coenzyme A + Benzoylsuccinyl-CoA <-> Succinyl-CoA + Benzoyl-CoA

Succinyl-CoA + Benzylsuccinate <-> Succinate + Benzylsuccinyl-CoA

Fumarate + Toluene <-> Benzylsuccinate

H2O + E-Phenylitaconyl-CoA <-> (Hydroxymethylphenyl)succinyl-CoA

H2O + NADP+ + 2-Methylbenzaldehyde <-> H+ + NADPH + o-Toluate

H2O + NADP+ + 3-Methylbenzaldehyde <-> H+ + NADPH + m-Methylbenzoate

NADH + H+ + O2 + m-Methylbenzoate <-> NAD+ + 1,6-Dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate

Toluene <-> 4-Cresol

H2O + 2-Hydroxy-cis-hex-2,4-dienoate <-> 4-Hydroxy-2-oxohexanoate

H2O + 2-Hydroxy-5-methyl-cis,cis-muconic semialdehyde <-> Formate + 2-Hydroxy-cis-hex-2,4-dienoate

NAD+ + H+ + 2 Reduced ferredoxin <-> NADH + 2 Oxidized ferredoxin

Pyruvate + Benzaldehyde <-> CO2 + R-Phenylacetylcarbinol

H2O + Acceptor + Benzylamine <-> NH3 + Benzaldehyde + Reduced acceptor

NAD+ + H2O + 3-Hydroxybenzaldehyde <-> NADH + H+ + 3-Hydroxybenzoate

2 Electron-transferring flavoprotein + Benzylsuccinyl-CoA <-> 2 Reduced electron-transferring flavoprotein + E-Phenylitaconyl-CoA

Succinyl-CoA + (R)-2-Benzylsuccinate <-> Succinate + (R)-2-Benzylsuccinyl-CoA

Classification

Xenobiotics Biodegradation and Metabolism