Pathway Details

Recommended name

Primary bile acid biosynthesis

Alternative names

Reactions

O2 + Cholesterol <-> H2O2 + Cholest-4-en-3-one

Acyl-CoA + Cholesterol <-> Coenzyme A + Cholesterol ester

H2O + Cholesterol ester <-> Carboxylate + Cholesterol

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + 7alpha-Hydroxycholesterol

Cholesterol + 1,2-Diacyl-sn-glycerol <-> Cholesterol ester + Acylglycerol

ATP + Coenzyme A + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> Diphosphate + AMP + Choloyl-CoA

H2O + Taurocholate <-> Taurine + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate

3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate <-> H2O + 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate

NAD+ + H2O + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate

NAD+ + 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestan-26-al

Glycine + Choloyl-CoA <-> Coenzyme A + Glycocholate

Propanoyl-CoA + Choloyl-CoA <-> Coenzyme A + 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA

Taurine + Choloyl-CoA <-> Coenzyme A + Taurocholate

ATP + Coenzyme A + Chenodeoxycholate <-> Diphosphate + AMP + Chenodeoxycholoyl-CoA

H2O + Glycochenodeoxycholate <-> Glycine + Chenodeoxycholate

H2O + Taurochenodeoxycholate <-> Taurine + Chenodeoxycholate

Chenodeoxycholate <-> 3alpha-Hydroxy-5beta-cholanate

NADP+ + 7alpha-Hydroxycholesterol <-> H+ + NADPH + 7alpha-Hydroxycholest-4-en-3-one

H2O + Glycodeoxycholate <-> Glycine + 3alpha,12alpha-Dihydroxy-5beta-cholanate

H2O + Taurodeoxycholate <-> Taurine + 3alpha,12alpha-Dihydroxy-5beta-cholanate

NAD+ + H2O + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestanate

ATP + Coenzyme A + 3alpha,7alpha-Dihydroxy-5beta-cholestanate <-> Diphosphate + AMP + 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

Propanoyl-CoA + Chenodeoxycholoyl-CoA <-> Coenzyme A + 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA

FAD + 3alpha,7alpha-Dihydroxy-5beta-cholestanoyl-CoA <-> FADH2 + 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA

ATP + Coenzyme A + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoate <-> Diphosphate + AMP + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA

FAD + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestanoyl-CoA <-> FADH2 + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

NAD+ + 3alpha,7alpha,26-Trihydroxy-5beta-cholestane <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-cholestan-26-al

H+ + NADPH + O2 + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H2O + NADP+ + 3alpha,7alpha,26-Trihydroxy-5beta-cholestane

H+ + NADPH + O2 + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H2O + NADP+ + 3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane

3alpha,7alpha,12alpha,26-Tetrahydroxy-5beta-cholestane <-> 5beta-Cyprinolsulfate

H2O + 3alpha,7alpha-Dihydroxy-5beta-cholest-24-enoyl-CoA <-> 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA

NAD+ + 3alpha,7alpha,24-Trihydroxy-5beta-cholestanoyl-CoA <-> NADH + H+ + 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA

Propanoyl-CoA + Chenodeoxyglycocholoyl-CoA <-> Coenzyme A + 3alpha,7alpha-Dihydroxy-5beta-24-oxocholestanoyl-CoA

NAD+ + 3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA <-> NADH + H+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-24-oxocholestanoyl-CoA

3alpha,7alpha,12alpha,24-Tetrahydroxy-5beta-cholestanoyl-CoA <-> H2O + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholest-24-enoyl-CoA

NADP+ + 7alpha-Hydroxy-5beta-cholestan-3-one <-> H+ + NADPH + 7alpha-Hydroxycholest-4-en-3-one

NAD+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha-Hydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha-Hydroxy-5beta-cholestan-3-one

NADP+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one <-> H+ + NADPH + 7alpha,12alpha-Dihydroxycholest-4-en-3-one

NAD+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> NADH + H+ + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane <-> H+ + NADPH + 7alpha,12alpha-Dihydroxy-5beta-cholestan-3-one

H+ + NADPH + O2 + 7alpha-Hydroxycholest-4-en-3-one <-> H2O + NADP+ + 7alpha,12alpha-Dihydroxycholest-4-en-3-one

7alpha,12alpha-Dihydroxycholest-4-en-3-one <-> 7alpha,12alpha-Dihydroxy-5alpha-cholestan-3-one

Glycine + Chenodeoxyglycocholoyl-CoA <-> Coenzyme A + Chenodeoxyglycocholate

H+ + NADPH + O2 + 27-Hydroxycholesterol <-> H2O + NADP+ + 7-alpha,27-Dihydroxycholesterol

H2O + Glycocholate <-> Glycine + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate

2 H+ + 3alpha,12alpha-Dihydroxy-5beta-chol-6-enoate <-> 3alpha,12alpha-Dihydroxy-5beta-cholanate

H+ + NADPH + O2 + Cholest-5-ene-3beta,26-diol <-> H2O + NADP+ + Cholest-5-ene-3beta,7alpha,26-triol

O2 + Cholesterol + Reduced acceptor <-> H2O + Acceptor + Cholest-5-ene-3beta,25-diol

H2O + Choloyl-CoA <-> Coenzyme A + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanate

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + 24-Hydroxycholesterol

H+ + NADPH + O2 + 24-Hydroxycholesterol <-> H2O + NADP+ + (24S)-Cholest-5-ene-3beta,7alpha,24-triol

H+ + NADPH + O2 + 3alpha,7alpha-Dihydroxy-5beta-cholestane <-> H2O + NADP+ + 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholestane

NAD+ + 7alpha-Hydroxycholesterol <-> NADH + H+ + 7alpha-Hydroxycholest-4-en-3-one

H+ + NADPH + O2 + Cholest-5-ene-3beta,25-diol <-> H2O + NADP+ + Cholest-5-ene-3beta,7alpha,25-triol

NADH + H+ + 3-Oxo-5beta-cholanate <-> NAD+ + 3beta-Hydroxy-5beta-cholanate

Taurine + Chenodeoxycholoyl-CoA <-> Coenzyme A + Taurochenodeoxycholate

Glycine + Chenodeoxycholoyl-CoA <-> Coenzyme A + Glycochenodeoxycholate

H+ + NADPH + O2 + Cholesterol <-> H2O + NADP+ + 24(S)-Hydroxycholesterol

Classification

Lipid Metabolism