Pathway Details

Recommended name

Pentose phosphate pathway

Alternative names

Phosphogluconate pathway

Hexose monophosphate shunt

HMP Shunt

Reactions

alpha-D-Glucose 6-phosphate <-> beta-D-Fructose 6-phosphate

beta-D-Fructose 6-phosphate + ATP <-> beta-D-Fructose 1,6-bisphosphate + ADP

beta-D-Fructose 1,6-bisphosphate <-> D-Glyceraldehyde 3-phosphate + Glycerone phosphate

alpha-D-Glucose 6-phosphate <-> beta-D-Glucose 6-phosphate

NADP+ + beta-D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone

beta-D-Fructose 1,6-bisphosphate + H2O <-> beta-D-Fructose 6-phosphate + Phosphate

beta-D-Fructose 6-phosphate + D-Glyceraldehyde 3-phosphate <-> D-Xylulose 5-phosphate + D-Erythrose 4-phosphate

beta-D-Fructose 6-phosphate + Diphosphate <-> beta-D-Fructose 1,6-bisphosphate + Phosphate

Phosphate + D-Fructose 6-phosphate <-> H2O + Acetyl phosphate + D-Erythrose 4-phosphate

D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate <-> D-Erythrose 4-phosphate + D-Fructose 6-phosphate

D-Ribulose 5-phosphate <-> D-Xylulose 5-phosphate

D-Glyceraldehyde 3-phosphate + D-Sedoheptulose 7-phosphate <-> D-Ribose 5-phosphate + D-Xylulose 5-phosphate

2-Deoxy-D-ribose 5-phosphate <-> D-Glyceraldehyde 3-phosphate + Acetaldehyde

D-Ribose 5-phosphate <-> D-Ribulose 5-phosphate

ATP + D-Ribose 5-phosphate <-> AMP + 5-Phospho-alpha-D-ribose 1-diphosphate

2-Deoxy-D-ribose 1-phosphate <-> 2-Deoxy-D-ribose 5-phosphate

NADP+ + 6-Phospho-D-gluconate <-> H+ + NADPH + CO2 + D-Ribulose 5-phosphate

H2O + 6-Phospho-D-glucono-1,5-lactone <-> 6-Phospho-D-gluconate

D-Ribose 1-phosphate <-> D-Ribose 5-phosphate

ATP + D-Ribose <-> ADP + D-Ribose 5-phosphate

Phosphate + D-Xylulose 5-phosphate <-> D-Glyceraldehyde 3-phosphate + H2O + Acetyl phosphate

CO2 + Acetyl-CoA + Reduced ferredoxin <-> Pyruvate + Coenzyme A + Oxidized ferredoxin

ADP + 2-Deoxy-D-ribose 5-phosphate <-> ATP + 2-Deoxy-D-ribose

ATP + D-Glycerate <-> ADP + 3-Phospho-D-glycerate

6-Phospho-2-dehydro-3-deoxy-D-gluconate <-> D-Glyceraldehyde 3-phosphate + Pyruvate

NADP+ + 6-Phospho-D-gluconate <-> H+ + NADPH + 6-Phospho-2-dehydro-D-gluconate

6-Phospho-D-gluconate <-> H2O + 6-Phospho-2-dehydro-3-deoxy-D-gluconate

D-Ribulose 5-phosphate + Formaldehyde <-> D-Arabino-6-hexulose 3-phosphate

NAD+ + 6-Phospho-D-gluconate <-> NADH + H+ + 6-Phospho-2-dehydro-D-gluconate

FAD + D-Gluconate <-> 2-Dehydro-D-gluconate + FADH2

2-Amino-2-deoxy-D-gluconate <-> Aminosugars

O2 + 2-Dehydro-D-glucose <-> H2O2 + 2-Dehydro-D-glucono-1,5-lactone

O2 + D-Glucose <-> 2-Dehydro-D-glucose + H2O2

D-Glucose + Acceptor <-> D-Glucono-1,5-lactone + Reduced acceptor

NADP+ + D-Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone

D-Glyceraldehyde 3-phosphate + H2O + NADP+ <-> Glycerate 3-phosphate + H+ + NADPH

D-Fructose 1,6-bisphosphate <-> D-Glyceraldehyde 3-phosphate + Glycerone phosphate

NADP+ + D-Galactose <-> H+ + NADPH + D-Galactono-1,5-lactone

H2O + D-Glucono-1,5-lactone <-> D-Gluconate

NAD+ + beta-D-Glucose <-> NADH + H+ + D-Glucono-1,5-lactone

NADP+ + beta-D-Glucose <-> H+ + NADPH + D-Glucono-1,5-lactone

O2 + beta-D-Glucose <-> H2O2 + D-Glucono-1,5-lactone

D-Ribulose 5-phosphate + Formaldehyde <-> 3-Oxohexulose 6-phosphate

D-Gluconate <-> H2O + 2-Dehydro-3-deoxy-D-gluconate

ATP + 2-Dehydro-3-deoxy-D-gluconate <-> ADP + 6-Phospho-2-dehydro-3-deoxy-D-gluconate

2-Amino-2-deoxy-D-gluconate <-> NH3 + 2-Dehydro-3-deoxy-D-gluconate

ATP + D-Gluconate <-> ADP + 6-Phospho-D-gluconate

NADP+ + D-Gluconate <-> H+ + NADPH + 2-Dehydro-D-gluconate

NAD+ + H2O + D-Glyceraldehyde <-> NADH + H+ + D-Glycerate

alpha-D-Ribose 1-phosphate <-> alpha-D-Ribose 5-phosphate

ATP + 2-Dehydro-D-gluconate <-> ADP + 6-Phospho-2-dehydro-D-gluconate

2-Dehydro-D-gluconate <-> H2O + 2-Dehydro-D-glucono-1,5-lactone

D-Glucose + Ubiquinone <-> D-Glucono-1,5-lactone + Ubiquinol

ATP + D-Ribose 1,5-bisphosphate <-> ADP + 5-Phospho-alpha-D-ribose 1-diphosphate

D-Ribose 1-phosphate <-> D-Ribose 1,5-bisphosphate

NADP+ + Glucose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-glucono-1,5-lactone

2-Keto-3-deoxy-D-gluconate <-> Pyruvate + D-Glyceraldehyde

2-Dehydro-3-deoxy-D-gluconate <-> Pyruvate + Glyceraldehyde

NADP+ + D-Glucose <-> H+ + NADPH + D-Glucono-1,5-lactone

NADP+ + D-Galactose 6-phosphate <-> H+ + NADPH + 6-Phospho-D-galactono-1,5-lactone

NADP+ + 2-Deoxy-D-glucose 6-phosphate <-> H+ + NADPH + 2-Deoxy-6-phospho-D-glucono-1,5-lactone

beta-D-Glucose + Acceptor <-> D-Glucono-1,5-lactone + Reduced acceptor

D-Glyceraldehyde 3-phosphate + H2O + NADP+ <-> H+ + NADPH + 3-Phospho-D-glycerate

D-Glyceraldehyde 3-phosphate + Sedoheptulose 7-phosphate <-> D-Ribose 5-phosphate + D-Xylulose 5-phosphate

NAD+ + 6-Phospho-D-gluconate <-> NADH + H+ + CO2 + D-Ribulose 5-phosphate

D-Sedoheptulose 7-phosphate + Glyceraldehyde 3-phosphate <-> D-Ribose 5-phosphate + D-Xylulose 5-phosphate

ATP + D-Glycerate <-> 2-Phospho-D-glycerate + ADP

Glucose 6-phosphate + Nicotinamide hypoxanthine dinucleotide phosphate <-> H+ + 6-Phospho-D-glucono-1,5-lactone + deamino-NADPH

D-Glyceraldehyde 3-phosphate + NAD+ + H2O <-> Glycerate 3-phosphate + NADH + H+

Pyruvate + D-Glyceraldehyde <-> 2-Dehydro-3-deoxy-D-gluconate

Classification

Carbohydrate Metabolism