Pathway Details

Recommended name

Histidine metabolism

Alternative names

Reactions

ATP + L-Histidine + tRNA(His) <-> Diphosphate + AMP + L-Histidyl-tRNA(His)

L-Glutamate + CO2 + NH3 <-> H2O + N-Carbamyl-L-glutamate

NH3 + 2-Oxoglutarate <-> H2O + 4-Oxoglutaramate

H2O + N-Formyl-L-glutamate <-> L-Glutamate + Formate

H2O + N-Formyl-L-aspartate <-> L-Aspartate + Formate

L-Phenylalanine + 2-Oxoglutarate <-> L-Glutamate + Phenylpyruvate

L-Tyrosine + 2-Oxoglutarate <-> L-Glutamate + 3-(4-Hydroxyphenyl)pyruvate

Diphosphate + Phosphoribosyl-ATP <-> ATP + 5-Phospho-alpha-D-ribose 1-diphosphate

L-Histidine + S-Adenosyl-L-methionine <-> S-Adenosyl-L-homocysteine + N(pai)-Methyl-L-histidine

L-Histidine + 2-Oxoglutarate <-> L-Glutamate + Imidazol-5-yl-pyruvate

2 NAD+ + H2O + L-Histidinal <-> 2 NADH + H+ + L-Histidine

ATP + L-Histidine + beta-Alanine <-> Diphosphate + AMP + Carnosine

H2O + Carnosine <-> L-Histidine + beta-Alanine

L-Histidine <-> CO2 + Histamine

L-Histidine <-> NH3 + Urocanate

L-Histidine + Activated methyl group <-> Hercynine

S-Adenosyl-L-methionine + Carnosine <-> S-Adenosyl-L-homocysteine + beta-Alanyl-N(pai)-methyl-L-histidine

H2O + O2 + Histamine <-> NH3 + H2O2 + Imidazole-4-acetaldehyde

Acetyl-CoA + Histamine <-> Coenzyme A + 4-(beta-Acetylaminoethyl)imidazole

S-Adenosyl-L-methionine + Histamine <-> S-Adenosyl-L-homocysteine + N-Methylhistamine

H2O + N-Formimino-L-glutamate <-> L-Glutamate + Formamide

H2O + N-Formimino-L-glutamate <-> NH3 + N-Formyl-L-glutamate

L-Glutamate + 5-Formiminotetrahydrofolate <-> 5,6,7,8-Tetrahydrofolate + N-Formimino-L-glutamate

H2O + 4-Imidazolone-5-propanoate <-> N-Formimino-L-glutamate

4-Imidazolone-5-propanoate <-> H2O + Urocanate

NAD+ + L-Histidinol <-> NADH + H+ + L-Histidinal

H2O + L-Histidinol phosphate <-> Phosphate + L-Histidinol

H2O + N-Formimino-L-aspartate <-> NH3 + N-Formyl-L-aspartate

L-Histidinol phosphate + 2-Oxoglutarate <-> L-Glutamate + 3-(Imidazol-4-yl)-2-oxopropyl phosphate

ATP + beta-Alanine + N(pai)-Methyl-L-histidine <-> H2O + Diphosphate + AMP + beta-Alanyl-N(pai)-methyl-L-histidine

ATP + beta-Alanine + N(pai)-Methyl-L-histidine <-> Diphosphate + AMP + beta-Alanyl-N(pai)-methyl-L-histidine

H2O + beta-Alanyl-N(pai)-methyl-L-histidine <-> beta-Alanine + N(pai)-Methyl-L-histidine

D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <-> H2O + 3-(Imidazol-4-yl)-2-oxopropyl phosphate

H2O + Phosphoribosyl-ATP <-> Diphosphate + Phosphoribosyl-AMP

H2O + Phosphoribosyl-AMP <-> 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide

NAD+ + H2O + Imidazole-4-acetaldehyde <-> NADH + H+ + Imidazole-4-acetate

NADH + H+ + O2 + Imidazole-4-acetate <-> NAD+ + H2O + 4-Imidazolone-5-acetate

ATP + H2O + 5-Phospho-alpha-D-ribose 1-diphosphate + Imidazole-4-acetate <-> ADP + Phosphate + Diphosphate + 1-(5-Phosphoribosyl)imidazole-4-acetate

CO2 + Imidazole-4-acetate <-> H2O + Imidazol-5-yl-pyruvate

N-Formimino-L-aspartate <-> H2O + 4-Imidazolone-5-acetate

H2O + 4-Imidazolone-5-propanoate <-> Formylisoglutamate

4-Imidazolone-5-propanoate <-> NH3 + Formate + 4-Oxoglutaramate

H2O + N1-(5-Phospho-D-ribosyl)-AMP <-> 5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide

H2O + 1-(5-Phosphoribosyl)imidazole-4-acetate <-> Phosphate + (1-Ribosylimidazole)-4-acetate

L-Glutamate + D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <-> L-Glutamine + 5'-Phospho-D-1-ribulosylformimine

L-Glutamate + 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + D-erythro-1-(Imidazol-4-yl)glycerol 3-phosphate <-> L-Glutamine + N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide

5-(5-Phospho-D-ribosylaminoformimino)-1-(5-phosphoribosyl)-imidazole-4-carboxamide <-> N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide

H2O + N-(5'-Phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phospho-D-ribosyl)-4-imidazolecarboxamide <-> 1-(5'-Phosphoribosyl)-5-amino-4-imidazolecarboxamide + 5'-Phospho-D-1-ribulosylformimine

H2O + O2 + N-Methylhistamine <-> NH3 + H2O2 + Methylimidazole acetaldehyde

Imidazol-5-yl-pyruvate <-> CO2 + Imidazole-4-acetaldehyde

H2O + Hydantoin-5-propionate <-> N-Carbamyl-L-glutamate

NADH + H+ + Imidazol-5-yl-pyruvate <-> NAD+ + Imidazole lactate

Ergothioneine <-> Trimethylamine + Thiourocanic acid

Ergothioneine <-> Hercynine

H2O + Formylisoglutamate <-> Isoglutamate

NAD+ + H2O + Methylimidazole acetaldehyde <-> NADH + H+ + Methylimidazoleacetic acid

L-Cysteine + O2 + Hercynine <-> H2O + S-(Hercyn-2-yl)-L-cysteine S-oxide

Reduced acceptor + S-(Hercyn-2-yl)-L-cysteine S-oxide <-> Pyruvate + NH3 + Acceptor + Ergothioneine

Classification

Amino Acid Metabolism