Pathway Details

Recommended name

Indole alkaloid biosynthesis

Alternative names

Reactions

L-Tryptophan <-> CO2 + Tryptamine

L-Tryptophan + Dimethylallyl diphosphate <-> Diphosphate + 4-(3-Methylbut-2-enyl)-L-tryptophan

Acetyl-CoA + Deacetylvindoline <-> Coenzyme A + Vindoline

H2O + Raucaffricine <-> D-Glucose + Vomilenine

H2O + 3-alpha(S)-Strictosidine <-> Tryptamine + Secologanin

H2O + 3-alpha(S)-Strictosidine <-> D-Glucose + Strictosidine aglycone

S-Adenosyl-L-methionine + 16-Methoxy-2,3-dihydro-3-hydroxytabersonine <-> S-Adenosyl-L-homocysteine + Desacetoxyvindoline

4,21-Dehydrocorynantheine aldehyde <-> 4,21-Dehydrogeissoschizine

H2O + Polyneuridine aldehyde <-> Methanol + CO2 + 16-Epivellosimine

16-Epivellosimine <-> Vellosimine

NADP+ + 10-Deoxysarpagine <-> H+ + NADPH + Vellosimine

Geissoschizine <-> Polyneuridine aldehyde

Strictosidine aglycone <-> Dialdehyde

H+ + Dialdehyde <-> H2O + 4,21-Dehydrocorynantheine aldehyde

4,21-Dehydrogeissoschizine <-> Cathenamine

Ajmalicine <-> Serpentine

4,21-Dehydrogeissoschizine <-> Stemmadenine

Stemmadenine <-> Tabersonine

Stemmadenine <-> Catharanthine

H+ + NADPH + O2 + Tabersonine <-> H2O + NADP+ + 16-Hydroxytabersonine

H2O + 16-Methoxytabersonine <-> 16-Methoxy-2,3-dihydro-3-hydroxytabersonine

O2 + 2-Oxoglutarate + Desacetoxyvindoline <-> CO2 + Succinate + Deacetylvindoline

Vindoline + Catharanthine <-> 3',4'-Anhydrovinblastine

3',4'-Anhydrovinblastine <-> Vinblastine

Vinblastine <-> Vincristine

H+ + NADPH + O2 + Tabersonine <-> H2O + NADP+ + Lochnericine

Lochnericine <-> Horhammericine

Tabersonine <-> Horhammericine

Tabersonine <-> Minovincinine

Acetyl-CoA + Minovincinine <-> Coenzyme A + Echitovenine

19-Hydroxytabersonine <-> Horhammericine

Tabersonine <-> 19-Hydroxytabersonine

4,21-Dehydrogeissoschizine <-> 19-epi-Cathenamine

Acetyl-CoA + 16-Epivellosimine <-> Coenzyme A + Vinorine

H+ + NADPH + O2 + Vinorine <-> H2O + NADP+ + Vomilenine

NADP+ + 1,2-Dihydrovomilenine <-> H+ + NADPH + Vomilenine

NADP+ + 17-O-Acetylnorajmaline <-> H+ + NADPH + 1,2-Dihydrovomilenine

H2O + 17-O-Acetylnorajmaline <-> Acetate + Norajmaline

S-Adenosyl-L-methionine + Norajmaline <-> S-Adenosyl-L-homocysteine + Ajmaline

UDPglucose + Vomilenine <-> UDP + Raucaffricine

S-Adenosyl-L-methionine + 16-Hydroxytabersonine <-> H+ + S-Adenosyl-L-homocysteine + 16-Methoxytabersonine

Tabersonine <-> Lochnerinine

H+ + NADPH + O2 + 10-Deoxysarpagine <-> H2O + NADP+ + Sarpagine

UDP-D-glucose + Vomilenine <-> UDP + Raucaffricine

NAD+ + Chanoclavine-I <-> NADH + H+ + Chanoclavine-I aldehyde

Acetyl-CoA + Fumigaclavine B <-> Coenzyme A + Fumigaclavine A

Classification

Biosynthesis of Other Secondary Metabolites

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