Pathway Details

Recommended name

O-Antigen nucleotide sugar biosynthesis

Alternative names

Reactions

D-Mannose 6-phosphate <-> beta-D-Fructose 6-phosphate

UTP + D-Glucose 1-phosphate <-> Diphosphate + UDPglucose

D-Mannose 6-phosphate <-> D-Mannose 1-phosphate

UDPglucose <-> UDPgalactose

UDPgalactose <-> UDP-D-galacto-1,4-furanose

GTP + D-Mannose 1-phosphate <-> Diphosphate + GDPmannose

GDPmannose <-> H2O + GDP-4-dehydro-D-rhamnose

2 NAD+ + H2O + UDPglucose <-> 2 NADH + H+ + UDPglucuronate

H2O + UDP-N-acetyl-D-glucosamine <-> UDP + N-Acetyl-D-mannosamine

UTP + N-Acetyl-alpha-D-glucosamine 1-phosphate <-> Diphosphate + UDP-N-acetyl-D-glucosamine

UDP-N-acetyl-D-glucosamine <-> UDP-N-acetyl-D-galactosamine

UDP-N-acetyl-D-glucosamine <-> UDP-N-acetyl-D-mannosamine

2 NAD+ + H2O + UDP-N-acetyl-D-glucosamine <-> 2 NADH + 2 H+ + UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate

CTP + D-Glucose 1-phosphate <-> Diphosphate + CDPglucose

CTP + N-Acetylneuraminate <-> Diphosphate + CMP-N-acetylneuraminate

UDPglucuronate <-> UDP-D-galacturonate

UDPglucuronate <-> UDP-L-iduronate

Phosphate + N-Acetylneuraminate <-> Phosphoenolpyruvate + H2O + N-Acetyl-D-mannosamine

D-Glucose 1-phosphate + dTTP <-> Diphosphate + dTDPglucose

CDPglucose <-> H2O + CDP-4-dehydro-6-deoxy-D-glucose

dTDPglucose <-> H2O + dTDP-4-dehydro-6-deoxy-D-glucose

dTDP-4-amino-4,6-dideoxy-D-glucose + 2-Oxoglutarate <-> L-Glutamate + dTDP-4-dehydro-6-deoxy-D-glucose

dTDP-4-dehydro-6-deoxy-D-glucose <-> dTDP-4-dehydro-beta-L-rhamnose

NADP+ + dTDP-6-deoxy-L-talose <-> H+ + NADPH + dTDP-4-dehydro-beta-L-rhamnose

NADP+ + dTDP-L-rhamnose <-> H+ + NADPH + dTDP-4-dehydro-beta-L-rhamnose

2 NAD+ + H2O + UDP-N-acetyl-D-mannosamine <-> 2 NADH + 2 H+ + UDP-N-acetyl-D-mannosaminouronate

NAD+ + H2O + CDP-4-dehydro-3,6-dideoxy-D-glucose <-> NADH + H+ + CDP-4-dehydro-6-deoxy-D-glucose

H2O + NADP+ + CDP-4-dehydro-3,6-dideoxy-D-glucose <-> H+ + NADPH + CDP-4-dehydro-6-deoxy-D-glucose

NAD+ + GDP-6-deoxy-D-talose <-> NADH + H+ + GDP-4-dehydro-D-rhamnose

NAD+ + GDP-D-rhamnose <-> NADH + H+ + GDP-4-dehydro-D-rhamnose

NADP+ + GDP-6-deoxy-D-talose <-> H+ + NADPH + GDP-4-dehydro-D-rhamnose

NADP+ + GDP-D-rhamnose <-> H+ + NADPH + GDP-4-dehydro-D-rhamnose

NADP+ + CDP-3,6-dideoxy-D-glucose <-> H+ + NADPH + CDP-4-dehydro-3,6-dideoxy-D-glucose

CDP-3,6-dideoxy-D-glucose <-> CDP-3,6-dideoxy-D-mannose

dTDP-4-amino-4,6-dideoxy-D-galactose + 2-Oxoglutarate <-> L-Glutamate + dTDP-4-dehydro-6-deoxy-D-galactose

UDP-2-acetamido-4-amino-2,4,6-trideoxyglucose + 2-Oxoglutarate <-> L-Glutamate + UDP-2-acetamido-4-dehydro-2,6-dideoxyglucose

dTDP-4-dehydro-6-deoxy-D-glucose <-> dTDP-3-oxo-6-deoxy-D-glucose

NADP+ + dTDP-D-fucose <-> H+ + NADPH + 4,6-Dideoxy-4-oxo-dTDP-D-glucose

L-Glutamate + 3,6-Dideoxy-3-oxo-dTDP-D-glucose <-> 2-Oxoglutarate + dTDP-3-amino-3,6-dideoxy-D-glucose

4,6-Dideoxy-4-oxo-dTDP-D-glucose <-> 3,6-Dideoxy-3-oxo-dTDP-D-glucose

dTDPglucose <-> H2O + 4,6-Dideoxy-4-oxo-dTDP-D-glucose

4,6-Dideoxy-4-oxo-dTDP-D-glucose <-> dTDP-4-dehydro-beta-L-rhamnose

2 NAD+ + H2O + UDP-N-acetyl-D-galactosamine <-> 2 NADH + 2 H+ + UDP-N-acetyl-D-galactosaminuronic acid

GTP + D-Mannose 1-phosphate <-> Diphosphate + GDP-D-mannose

2 NAD+ + H2O + UDP-D-glucose <-> 2 NADH + H+ + UDPglucuronate

GDP-D-mannose <-> H2O + n+1 GDP-4-dehydro-D-rhamnose

UDP-D-galactose <-> UDP-D-galacto-1,4-furanose

alpha-D-Glucose 1-phosphate + dTTP <-> Diphosphate + dTDP-D-glucose

dTDP-D-glucose <-> H2O + dTDP-4-dehydro-6-deoxy-D-glucose

UTP + alpha-D-Glucose 1-phosphate <-> Diphosphate + UDP-D-glucose

UDP-D-glucose <-> UDP-D-galactose

dTDP-D-glucose <-> H2O + 4,6-Dideoxy-4-oxo-dTDP-D-glucose

NADP+ + GDP-L-fucose <-> H+ + NADPH + GDP-4-dehydro-D-rhamnose

CTP + alpha-D-Glucose 1-phosphate <-> Diphosphate + CDPglucose

Acetyl-CoA + dTDP-4-amino-4,6-dideoxy-D-glucose <-> Coenzyme A + dTDP-4-acetamido-4,6-dideoxy-D-glucose

Classification