Pathway Details

Recommended name

Peptidoglycan biosynthesis

Alternative names

Reactions

Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine <-> Phosphate + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine

ATP + 2 D-Alanine <-> ADP + Phosphate + D-Alanyl-D-alanine

ATP + D-Glutamate + UDP-N-acetylmuramoyl-L-alanine <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate

ATP + L-Lysine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine

ATP + L-Lysine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine

ATP + meso-2,6-Diaminoheptanedioate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate

D-Alanine + Crosslinked peptideglycan <-> Peptidoglycan

NAD+ + UDP-N-acetylmuramate <-> NADH + H+ + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine

NADP+ + UDP-N-acetylmuramate <-> H+ + NADPH + UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine

ATP + L-Alanine + UDP-N-acetylmuramate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanine

H2O + N-Acetyl-D-muramoyl-L-alanine <-> L-Alanine + N-Acetyl-D-muramoate

Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine + [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-g-D-Glu-A2pm-D-Ala-D-Ala)]n-diphosphoundecaprenol <-> Undecaprenyl diphosphate + [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-g-D-Glu-A2pm-D-Ala-D-Ala)]n-diphosphoundecaprenol

ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <-> ADP + Phosphate + UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)

H2O + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine <-> D-Alanine + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanine

ATP + D-Alanyl-D-alanine + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminopimelate <-> ADP + Phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine

UDP-N-acetyl-D-glucosamine + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine <-> UDP + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

ATP + NH3 + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine <-> ADP + Phosphate + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-L-lysyl-D-alanyl-D-alanine

5 Glycyl-tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-L-lysyl-D-alanyl-D-alanine <-> 5 tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine

ATP + NH3 + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine <-> ADP + Phosphate + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine

5 Glycyl-tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-D-alanyl-D-alanine <-> 5 tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-isoglutaminyl-L-lysyl-(glycyl)5-D-alanyl-D-alanine

UDP-N-acetyl-D-glucosamine + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <-> UDP + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

ATP + NH3 + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <-> ADP + Phosphate + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

5 Glycyl-tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine <-> 5 tRNA(Gly) + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-D-glutaminyl-meso-2,6-diaminopimeloyl-(glycyl)5-D-alanyl-D-alanine

ATP + Undecaprenol <-> ADP + Undecaprenyl phosphate

H2O + Undecaprenyl diphosphate <-> Phosphate + Undecaprenyl phosphate

Undecaprenyl phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine <-> UMP + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine

Undecaprenyl phosphate + UDPMurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala) <-> UMP + MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol

Undecaprenyl phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine <-> UMP + Undecaprenyl-diphospho-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D-alanyl-D-alanine

UDP-N-acetyl-D-glucosamine + MurAc(oyl-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala)-diphospho-undecaprenol <-> UDP + Undecaprenyl-diphospho-N-acetylmuramoyl-(N-acetylglucosamine)-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

Classification

Glycan Biosynthesis and Metabolism

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