Reaction Details

Stochiometric Equation NAD+ + 5,10-Methylenetetrahydrofolate <-> NADH + H+ + 5,10-Methenyltetrahydrofolate
Substrates
NAD+
5,10-Methylenetetrahydrofolate
Products
5,10-Methenyltetrahydrofolate
NADH
H+
Enzymes known to catalyse this reaction (curated information)
EC Numberin OrganismUniProt LinkPubMedID
1.5.1.15 Homo sapiens UniProt 1392622
1.5.1.15 Homo sapiens UniProt 3258307
1.5.1.15 Homo sapiens UniProt 8218174
1.5.1.15 Mus musculus UniProt 3487546
1.5.1.15 Saccharomyces cerevisiae UniProt 2223762
1.5.1.5 Clostridium formicaceticum UniProt 4153026
1.5.1.5 Photobacterium phosphoreum UniProt 8765228
Pathways Biosynthesis of cofactors
Metabolic pathways
One carbon pool by folate


View all entries for reaction NAD+ + 5,10-Methylenetetrahydrofolate <-> NADH + H+ + 5,10-Methenyltetrahydrofolate