Reaction Details

Stochiometric Equation 7 Malonyl-CoA + 2-Methylpropanoyl-CoA + 5 2-Methylmalonyl-CoA <-> 13 Coenzyme A + 12 CO2 + 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone
Substrates
Malonyl-CoA
2-Methylpropanoyl-CoA
2-Methylmalonyl-CoA
Products
Coenzyme A
CO2
6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone
Enzymes known to catalyse this reaction (curated information)
EC Numberin OrganismUniProt LinkPubMedID
Pathways Biosynthesis of 12-, 14- and 16-membered macrolides


View all entries for reaction 7 Malonyl-CoA + 2-Methylpropanoyl-CoA + 5 2-Methylmalonyl-CoA <-> 13 Coenzyme A + 12 CO2 + 6,8a-Seco-6,8a-deoxy-5-oxoavermectin ''2b'' aglycone