Reaction Details

Stochiometric Equation H+ + NADPH + 5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + NADP+ + 5,6,7,8-Tetrahydrofolate
Substrates
dUMP
H+
5,10-Methylenetetrahydrofolate
NADPH
Products
dTMP
5,6,7,8-Tetrahydrofolate
NADP+
Enzymes known to catalyse this reaction (curated information)
EC Numberin OrganismUniProt LinkPubMedID
2.1.1.148 Chlamydia trachomatis UniProt 15591067
2.1.1.148 Thermotoga maritima UniProt 15301527
Complex 1.5.1.3/2.1.1.45 Leishmania major UniProt 12556445
Complex 1.5.1.3/2.1.1.45 Toxoplasma gondii UniProt 12556445
Pathways Metabolic pathways
One carbon pool by folate
Pyrimidine metabolism


View all entries for reaction H+ + NADPH + 5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + NADP+ + 5,6,7,8-Tetrahydrofolate