<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version3" level="2" version="3">
  <model name="SABIOmdl08Apr2026308">
<notes><body xmlns="http://www.w3.org/1999/xhtml">
<p>
This model has been created with the help of the SABIO-RK Database
(http://sabio.h-its.org/) 
 (c) 2005-2026 HITS gGmbH http://www.h-its.org

</p><br/>
To cite SABIO-RK Database, please use
"http://www.ncbi.nlm.nih.gov/pubmed/22102587"
<br/>
SABIO-RK - database for biochemical reaction kinetics. Wittig U, Kania R, Golebiewski M, Rey M, Shi L, Jong L, Algaa E, Weidemann A, Sauer-Danzwith H, Mir S, Krebs O, Bittkowski M, Wetsch E, Rojas I, Mueller W. Nucleic Acids Res. 2012;40(Database issue)790-6
</body></notes>
      <listOfFunctionDefinitions>
      <functionDefinition id="KL_123">
        <math xmlns="http://www.w3.org/1998/Math/MathML">        
          <lambda>
            <bvar>
              <ci> B </ci>
            </bvar>
            <bvar>
              <ci> k_cat </ci>
            </bvar>
            <bvar>
              <ci> Km </ci>
            </bvar>
            <bvar>
              <ci> A </ci>
            </bvar>
            <notanumber/>
          </lambda>
        </math>
      </functionDefinition>
    </listOfFunctionDefinitions>
    <listOfUnitDefinitions>
      <unitDefinition id="swedgeone" name="s^(-1)">
        <listOfUnits>
          <unit scale="1" exponent="-1" multiplier="1" kind="second"/>
        </listOfUnits>
      </unitDefinition>
      <unitDefinition id="M" name="M">
        <listOfUnits>
          <unit scale="1" exponent="-1" multiplier="1" kind="litre"/>
          <unit scale="1" exponent="1" multiplier="1" kind="mole"/>
        </listOfUnits>
      </unitDefinition>
    </listOfUnitDefinitions>
    <listOfCompartments>
      <compartment id="compart_Cell" constant="true" name="Cell"/>
    </listOfCompartments>
    <listOfSpecies>
      <species id="SPC_1336_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="Dihydrofolate" metaid="META_SPC_1336_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1336_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:15633"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:57451"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:4564"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:42000"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:20768"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:14150"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:12245"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00415"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_1262_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="NADPH" metaid="META_SPC_1262_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1262_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:16474"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:7425"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:57783"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:44286"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:21904"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:13400"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:13399"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00005"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_39_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="H+" metaid="META_SPC_39_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_39_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:15378"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:5584"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:29234"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:29233"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:24636"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:13357"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:10744"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00080"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_1263_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="NADP+" metaid="META_SPC_1263_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1263_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:44409"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:25523"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:18009"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:7424"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:58349"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:44405"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:21903"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:13398"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:13397"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00006"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C11037"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="SPC_1297_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="5,6,7,8-Tetrahydrofolate" metaid="META_SPC_1297_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_SPC_1297_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:26911"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:20506"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:15635"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:9482"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:68437"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:57453"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:46069"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:18606"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:15220"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:12075"/>
                  <rdf:li rdf:resource="urn:miriam:chebi:CHEBI:10931"/>
                  <rdf:li rdf:resource="urn:miriam:kegg.compound:C00101"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
      <species id="ENZ_139470_Cell" initialConcentration="1" constant="false" hasOnlySubstanceUnits="false" name="dihydrofolate reductase(Enzyme) mutant DHFR N59K" metaid="META_ENZ_139470_Cell" boundaryCondition="false" compartment="compart_Cell">
        <annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:modifierType>Modifier-Catalyst</sbrk:modifierType>
</sbrk:sabiork>                  <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_ENZ_139470_Cell">
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:uniprot:P0ABQ4"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
</species>
    </listOfSpecies>
    <listOfReactions>
      <reaction id="REAC_0" metaid="META_REAC_0" reversible="true" fast="false">
        <annotation>
          <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
            <rdf:Description rdf:about="#META_REAC_0">
              <bqbiol:isVersionOf>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:ec-code:1.5.1.3"/>
                </rdf:Bag>
              </bqbiol:isVersionOf>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:kegg.reaction:R00939"/>
                </rdf:Bag>
              </bqbiol:is>
              <bqbiol:is>
                <rdf:Bag>
                  <rdf:li rdf:resource="urn:miriam:sabiork.reaction:100"/>
                </rdf:Bag>
              </bqbiol:is>
            </rdf:Description>
          </rdf:RDF>
        </annotation>
        <listOfReactants>
          <speciesReference species="SPC_1336_Cell" sboTerm="SBO:0000015" stoichiometry="1"/>
          <speciesReference species="SPC_1262_Cell" sboTerm="SBO:0000015" stoichiometry="1"/>
          <speciesReference species="SPC_39_Cell" sboTerm="SBO:0000015" stoichiometry="1"/>
        </listOfReactants>
        <listOfProducts>
          <speciesReference species="SPC_1263_Cell" sboTerm="SBO:0000011" stoichiometry="1"/>
          <speciesReference species="SPC_1297_Cell" sboTerm="SBO:0000011" stoichiometry="1"/>
        </listOfProducts>
        <listOfModifiers>
          <modifierSpeciesReference species="ENZ_139470_Cell" sboTerm="SBO:0000460"/>
        </listOfModifiers>
        <kineticLaw metaid="META_KL_123">
          <annotation>
<sbrk:sabiork xmlns:sbrk="http://sabiork.h-its.org">
<sbrk:kineticLawID>123</sbrk:kineticLawID>
<sbrk:experimentalConditions>
<sbrk:temperature>
<sbrk:startValueTemperature>15.0</sbrk:startValueTemperature>
<sbrk:temperatureUnit>°C</sbrk:temperatureUnit>
</sbrk:temperature>
<sbrk:pH>
<sbrk:startValuepH>7.0</sbrk:startValuepH>
</sbrk:pH>
<sbrk:buffer> 50 mM Morpholinoethanesulfonic acid, 25 mM tris(hydroxymethyl)aminomethane, 25 mM ethanolamine, 100 mM NaCl, 14 mM 2-mercaptoethanol</sbrk:buffer>
</sbrk:experimentalConditions>
</sbrk:sabiork>
                      <rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" xmlns:bqmodel="http://biomodels.net/model-qualifiers/">
              <rdf:Description rdf:about="#META_KL_123">
                <bqbiol:isDescribedBy>
                  <rdf:Bag>
                    <rdf:li rdf:resource="urn:miriam:pubmed:15740745"/>
                  </rdf:Bag>
                </bqbiol:isDescribedBy>
                <bqbiol:isDescribedBy>
                  <rdf:Bag>
                    <rdf:li rdf:resource="urn:miriam:sabiork.kineticrecord:123"/>
                  </rdf:Bag>
                </bqbiol:isDescribedBy>
              </rdf:Description>
            </rdf:RDF>
          </annotation>
          <math xmlns="http://www.w3.org/1998/Math/MathML">          
            <apply>
              <ci> KL_123 </ci>
              <ci> SPC_1336_Cell </ci>
              <ci> k_cat </ci>
              <ci> Km_SPC_1336_Cell </ci>
              <ci> SPC_1262_Cell </ci>
            </apply>
          </math>
                  <listOfParameters>
            <parameter id="k_cat" name="k_cat" value="4.3" sboTerm="SBO:0000025" units="swedgeone"/>
            <parameter id="Km_SPC_1336_Cell" name="Km_Dihydrofolate" value="1.36E-5" sboTerm="SBO:0000027" units="M"/>
          </listOfParameters>
        </kineticLaw>
      </reaction>
    </listOfReactions>
  </model>
</sbml>