1.0 Hexanoate N-Acetyl-D-sphingosine thymidine kinase(Enzyme) wildtype SPC_25130_lysosome SPC_1302_mitochondrion 1.0 1.0 5'-Deoxy-5'-(methylthio)adenosine 1.0 SPC_1315_mitochondrion 1.0 SPC_2122_cytosol Phosphatidylinositol 1.0 1.0 SPC_1278_lysosome 1.0 SPC_6916_Cell SPC_20032_lysosome 1.0 1.0 SPC_40_lysosome SPC_5422_membrane thymidine kinase(Enzyme) wildtype 1.0 1.0 1.0 thymidine kinase(Enzyme) wildtype SPC_35_mitochondrion SPC_34_mitochondrion SPC_35_mitochondrion 1.0 SPC_65_mitochondrion 1.0 SPC_2178_mitochondrion 1.0 SPC_34_mitochondrion 1.0 Putrescine SPC_40_Cell SPC_40_lysosome 1.0 Octanoate 1.0 ceramidase(Enzyme) wildtype 1.0 SPC_2297_lysosome thymidine kinase(Enzyme) wildtype SPC_63_mitochondrion 1.0 1.0 ceramidase(Enzyme) wildtype N-Palmitoylsphinganine SPC_5264_lysosome 1.0 1.0 1.0 ceramidase(Enzyme) wildtype Heparin alpha-D-Galactose thymidine kinase(Enzyme) wildtype REAC_25 REAC_26 REAC_27 1.0 REAC_28 REAC_21 REAC_22 REAC_23 ATP REAC_24 REAC_29 SPC_2178_mitochondrion SPC_63_mitochondrion REAC_31 REAC_30 1.0 1.0 1.0 REAC_38 SPC_1315_mitochondrion REAC_39 REAC_36 REAC_37 REAC_34 REAC_35 REAC_32 REAC_33 1.0 SPC_1960_Cell SPC_27854_mitochondrion SPC_35_mitochondrion 1D-myo-Inositol 1-phosphate SPC_40_lysosome SPC_1286_mitochondrion REAC_41 REAC_40 thymidine kinase(Enzyme) wildtype SPC_1315_mitochondrion 1.0 SPC_35_mitochondrion SPC_25149_lysosome SPC_65_mitochondrion SPC_65_mitochondrion Diacylglycerol 1.0 SPC_1315_mitochondrion 1.0 N-Hexanoyl-D-erythro-sphingosine 1.0 SPC_25148_lysosome beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A Sphinganine SPC_1302_mitochondrion Oleate 1.0 thymidine kinase(Enzyme) wildtype 1.0 1.0 SPC_40_lysosome SPC_27853_mitochondrion 1.0 1.0 1.0 1.0 1.0 CTP 1.0 SPC_2488_lysosome SPC_5042_lysosome Sphingosine SPC_65_mitochondrion SPC_5042_lysosome S-Adenosylmethioninamine thymidine kinase(Enzyme) wildtype 1.0 alpha-galactosidase(Enzyme) wildtype SPC_1941_Cell 1.0 SPC_3088_Cell SPC_5404_Cell 1.0 1.0 1.0 SPC_65_mitochondrion 1.0 SPC_5264_lysosome SPC_25141_lysosome SPC_35_mitochondrion SPC_35_mitochondrion 1.0 1.0 1.0 1.0 ceramidase(Enzyme) wildtype 1.0 dTMP beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B CDP SPC_1315_mitochondrion 1.0 1.0 SPC_63_mitochondrion 1.0 1.0 SPC_40_lysosome SPC_5013_membrane SPC_35_mitochondrion SPC_63_mitochondrion 1.0 1.0 1.0 SPC_21081_lysosome SPC_35_mitochondrion 1.0 SPC_25159_lysosome ceramidase(Enzyme) wildtype SPC_2178_mitochondrion thymidine kinase(Enzyme) wildtype phosphoinositide phospholipase C(Enzyme) wildtype SPC_90_lysosome 1.0 SPC_35_mitochondrion 1.0 1.0 ceramidase(Enzyme) wildtype REAC_20 1.0 SPC_2074_mitochondrion REAC_19 Cell REAC_18 1.0 SPC_34_mitochondrion SPC_40_Cell REAC_11 REAC_10 REAC_13 REAC_12 3'-Fluoro-2',3'-dideoxythymidine REAC_15 REAC_14 SPC_34_mitochondrion REAC_17 REAC_16 ceramidase(Enzyme) wildtype 1.0 H2O 1.0 SPC_63_mitochondrion 1.0 1.0 1.0 4-Methylumbelliferyl-alpha-D-galactoside 1.0 1.0 1.0 1.0 SPC_34_mitochondrion 4-Methylumbelliferyl-beta-N-acetylglucosaminide SPC_65_mitochondrion SPC_2074_mitochondrion 1.0 SPC_1941_Cell SPC_1334_mitochondrion 1.0 1.0 1.0 1.0 SPC_23010_Cell 1.0 SPC_6439_Cell 1.0 1.0 SPC_1315_mitochondrion thymidine kinase(Enzyme) wildtype N-Oleoyl-D-sphingosine 3'-Azido-2',3'-dideoxythymidine ADP SPC_2178_mitochondrion 1.0 1.0 SPC_35_mitochondrion 1.0 SPC_40_membrane SPC_35_mitochondrion SPC_1990_lysosome 4-Methylumbelliferone thymidine kinase(Enzyme) wildtype 1.0 1.0 1.0 1.0 thymidine kinase(Enzyme) wildtype SPC_5404_Cell thymidine kinase(Enzyme) wildtype 1.0 1.0 1.0 SPC_6439_Cell H2O SPC_1315_mitochondrion SPC_65_mitochondrion SPC_6439_Cell SPC_5042_lysosome SPC_40_lysosome SPC_34_mitochondrion SPC_1334_mitochondrion 1.0 thymidine kinase(Enzyme) wildtype 1.0 lysosome SPC_25150_lysosome SPC_2178_mitochondrion 5-Fluorodeoxyuridine 5'-phosphate SPC_1334_mitochondrion SPC_40_lysosome cytosol 1.0 SPC_34_mitochondrion 1.0 1.0 beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A 1.0 SPC_35_mitochondrion 1.0 1.0 1.0 1.0 1.0 1.0 1.0 SPC_1315_mitochondrion 4-Methylumbelliferone thymidine kinase(Enzyme) wildtype 1.0 SPC_35_mitochondrion 1.0 1.0 1.0 1.0 SPC_34_mitochondrion 1.0 1.0 Diacylglycerol SPC_35_mitochondrion 1.0 SPC_2074_mitochondrion 1.0 1.0 SPC_35_mitochondrion SPC_35_mitochondrion 1.0 1D-myo-Inositol 1-phosphate H2O Acetate Spermidine SPC_40_lysosome thymidine kinase(Enzyme) wildtype N-Dodecanoylsphingosine 1.0 membrane 1.0 SPC_1286_mitochondrion 1.0 1.0 SPC_34_mitochondrion 1.0 SPC_65_mitochondrion SPC_2074_mitochondrion SPC_2074_mitochondrion SPC_13796_mitochondrion 1.0 N-Octanoyl-D-sphingosine 1.0 SPC_2889_lysosome SPC_25151_lysosome N-Acetyl-beta-D-glucosamine 1.0 1.0 SPC_5042_lysosome SPC_23010_Cell 2',3'-Didehydro-2',3'-dideoxythymidine SPC_1334_mitochondrion SPC_23010_Cell 1.0 1.0 SPC_40_cytosol SPC_34_mitochondrion dCTP thymidine kinase(Enzyme) wildtype spermidine synthase(Enzyme) wildtype SPC_34_mitochondrion 1.0 thymidine kinase(Enzyme) wildtype 1.0 1.0 1.0 1.0 2'-Deoxycytidine thymidine kinase(Enzyme) wildtype SPC_34_mitochondrion SPC_5042_lysosome SPC_40_Cell SPC_5042_lysosome SPC_23010_Cell 1.0 SPC_2122_membrane This BioPAX Level3 file was automatically generated on Apr 8, 2026 by SBML2BioPAX-3.1, BioModels.net, EMBL-EBI. SPC_1334_mitochondrion SPC_35_mitochondrion thymidine kinase(Enzyme) wildtype SPC_6916_Cell SPC_40_lysosome SPC_6439_Cell Phosphatidylinositol 1.0 1.0 SPC_35_mitochondrion 1.0 SPC_34_mitochondrion 1.0 1.0 1.0 1.0 SPC_6916_Cell Stearate 2'-Deoxyuridine H2O SPC_34_mitochondrion 1.0 SPC_28371_lysosome REAC_2 REAC_1 REAC_4 1.0 SPC_35_mitochondrion REAC_3 REAC_6 SPC_65_mitochondrion 1.0 REAC_5 SPC_1315_mitochondrion REAC_8 REAC_7 1.0 thymidine kinase(Enzyme) wildtype REAC_9 1.0 SPC_34_mitochondrion 1.0 SPC_40_Cell 1.0 SPC_6439_lysosome ceramidase(Enzyme) wildtype N-Stearoyl-D-sphingosine 1.0 SPC_5422_cytosol REAC_0 SPC_34_mitochondrion 1.0 SPC_1960_Cell SPC_40_lysosome SPC_34_mitochondrion 1.0 spermidine synthase(Enzyme) wildtype SPC_2488_lysosome SPC_34_mitochondrion SPC_34_mitochondrion dUMP Palmitate SPC_6916_Cell SPC_27852_mitochondrion 1.0 1.0 1.0 SPC_34_mitochondrion 1.0 1.0 SPC_1315_mitochondrion 1.0 SPC_3088_Cell SPC_34_mitochondrion N-Octanoylsphinganine Dodecanoate SPC_65_mitochondrion thymidine kinase(Enzyme) wildtype SPC_2178_mitochondrion SPC_1315_mitochondrion 1.0 SPC_65_mitochondrion 1.0 SPC_63_mitochondrion dCMP SPC_2139_lysosome 1.0 beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B SPC_35_mitochondrion SPC_21081_lysosome Thymidine SPC_2889_lysosome SPC_5042_lysosome thymidine kinase(Enzyme) wildtype SPC_35_mitochondrion 1.0 3'-Azido-2',3'-dideoxythymidine 5'-phosphate 1.0 mitochondrion 1.0 dTTP 1.0 ceramidase(Enzyme) wildtype SPC_34_mitochondrion 1.0 5-Fluorodeoxyuridine phosphoinositide phospholipase C(Enzyme) wildtype 1.0 SPC_35_mitochondrion SPC_5013_cytosol 1.0 thymidine kinase(Enzyme) wildtype