# # This file is automatically generated with # the System Biology Format Converter (http://sbfc.sourceforge.net/) # from an SBML file. # # # Model name = SABIOmdl26Dec2024407 # # # some function definitions that are allowed in SBML but not valid in xpp ceil(x)=flr(1+x) @delay=50 # FunctionDefinition id = KL_39851 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_39850 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_50493 KL_50493(Vmax,S,Km)=(Vmax*S/(S+Km)) # FunctionDefinition id = KL_41756 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41757 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41754 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41755 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41750 KL_41750(Km,A,Vmax,S)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41752 KL_41752(S,A,Km,Vmax)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41751 KL_41751(S,Vmax,Km,A)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41749 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41753 KL_41753(S,Vmax,Km,A)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41758 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41759 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41766 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41765 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41764 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41763 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41762 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41760 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41761 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41745 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41746 KL_41746(Vmax_Km,S,Vmax,Km,A)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41747 KL_41747(A,Vmax_Km,Vmax,Km,S)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41748 KL_41748(Km,S,Vmax_Km,A,Vmax)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_41768 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_41767 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_39577 KL_39577(S,Km,Vmax)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_39576 KL_39576(Vmax,S,Km)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_48160 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_48161 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_48158 KL_48158(Km,Vmax,A)=(Vmax*A/(Km+A)) # FunctionDefinition id = KL_48159 KL_48159(Km,Vmax,A)=(Vmax*A/(Km+A)) # FunctionDefinition id = KL_21313 KL_21313(Km,S,Vmax)=(Vmax*S/(Km+S)) # FunctionDefinition id = KL_21319 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21316 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21321 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21314 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21315 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21317 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21318 # Inconsistent mathML operators in Function Definition, function ignored # FunctionDefinition id = KL_21320 # Inconsistent mathML operators in Function Definition, function ignored # Compartment: id = compart_cytosol, name = cytosol, constant par compart_c=NaN # Compartment: id = compart_membrane, name = membrane, constant par compart_m=NaN # Compartment: id = compart_lysosome, name = lysosome, constant par compart_l=NaN # Compartment: id = compart_mitochondrion, name = mitochondrion, constant par compart_1=NaN # Compartment: id = compart_Cell, name = Cell, constant par compart_2=NaN # Reaction: id = REAC_0 # Local Parameter: id = Km_SPC_2122_cytosol, name = Km_Phosphatidylinositol par Km_SPC_21=1.5E-6 REAC_0=KL_39851(Km_SPC_21) # Reaction: id = REAC_1 # Local Parameter: id = Km_SPC_2122_membrane, name = Km_Phosphatidylinositol par Km_SPC__1=5.0E-6 REAC_1=KL_39850(Km_SPC__1) # Reaction: id = REAC_2 # Local Parameter: id = Km_SPC_28371_lysosome, name = Km_4MethylumbelliferylalphaDgalactoside par Km_SPC_28=0.003 REAC_2=KL_50493(Vmax, SPC_28371, Km_SPC_28) # Reaction: id = REAC_3 # Local Parameter: id = Ki_SPC_27857_mitochondrion, name = Ki_two3Didehydrotwo3dideoxythymidine par Ki_SPC_27=7.8E-5 REAC_3=KL_41756(Ki_SPC_27, SPC_34_mi, SPC_1315_) # Reaction: id = REAC_4 # Local Parameter: id = Ki_SPC_13796_mitochondrion, name = Ki_5Fluorodeoxyuridine par Ki_SPC_13=1.3E-5 REAC_4=KL_41757(Ki_SPC_13, SPC_34_mi, SPC_1315_) # Reaction: id = REAC_5 # Local Parameter: id = Ki_SPC_27854_mitochondrion, name = Ki_3Azidotwo3dideoxythymidine par Ki_SPC__1=2.0E-6 REAC_5=KL_41754(SPC_1315_, SPC_34_mi, Ki_SPC__1) # Reaction: id = REAC_6 # Local Parameter: id = Ki_SPC_27856_mitochondrion, name = Ki_3Fluorotwo3dideoxythymidine par Ki_SPC__2=1.0E-5 REAC_6=KL_41755(SPC_34_mi, Ki_SPC__2, SPC_1315_) # Reaction: id = REAC_7 # Local Parameter: id = Km_SPC_34_mitochondrion, name = Km_ATP par Km_SPC_34=2.0E-6 REAC_7=KL_41750(Km_SPC_34, SPC_1315_, Vmax_1, SPC_34_mi) # Reaction: id = REAC_8 # Local Parameter: id = Km_SPC_34_mitochondrion, name = Km_ATP par Km_SPC__2=3.0E-6 REAC_8=KL_41752(SPC_34_mi, SPC_2178_, Km_SPC__2, Vmax_1_2) # Reaction: id = REAC_9 # Local Parameter: id = Km_SPC_1286_mitochondrion, name = Km_CTP par Km_SPC_12=6.0E-6 REAC_9=KL_41751(SPC_1286_, Vmax_1__3, Km_SPC_12, SPC_1315_) # Reaction: id = REAC_10 # Local Parameter: id = n_SPC_27854_mitochondrion, name = n_3Azidotwo3dideoxythymidine par n_SPC_278=0.4 # Local Parameter: id = Vmax_Km_SPC_27854_mitochondrion, name = Vmax_Km_3Azidotwo3dideoxythymidine par Vmax_Km_S=2.666667 # Local Parameter: id = Km2_SPC_27854_mitochondrion, name = Km2_3Azidotwo3dideoxythymidine par Km2_SPC_2=9.0E-5 # Local Parameter: id = Km1_SPC_27854_mitochondrion, name = Km1_3Azidotwo3dideoxythymidine par Km1_SPC_2=2.0E-7 # Local Parameter: id = Vmax, name = Vmax par Vmax_1__4=5.333333E-7 REAC_10=KL_41749(n_SPC_278, Vmax_Km_S, Km2_SPC_2, Km1_SPC_2, SPC_34_mi, Vmax_1__4) # Reaction: id = REAC_11 # Local Parameter: id = Km_SPC_1286_mitochondrion, name = Km_CTP par Km_SPC__3=9.0E-6 REAC_11=KL_41753(SPC_1286_, Vmax_1__5, Km_SPC__3, SPC_2178_) # Reaction: id = REAC_12 # Local Parameter: id = Ki_SPC_2074_mitochondrion, name = Ki_twoDeoxyuridine par Ki_SPC_20=7.5E-5 REAC_12=KL_41758(SPC_1315_, SPC_34_mi, Ki_SPC_20) # Reaction: id = REAC_13 # Local Parameter: id = Ki_SPC_2178_mitochondrion, name = Ki_twoDeoxycytidine par Ki_SPC_21=6.3E-4 REAC_13=KL_41759(SPC_1315_, Ki_SPC_21, SPC_34_mi) # Reaction: id = REAC_14 # Local Parameter: id = Ki_SPC_2074_mitochondrion, name = Ki_twoDeoxyuridine par Ki_SPC__3=6.9E-4 REAC_14=KL_41766(SPC_34_mi, SPC_2178_, Ki_SPC__3) # Reaction: id = REAC_15 # Local Parameter: id = Ki_SPC_1315_mitochondrion, name = Ki_Thymidine par Ki_SPC__4=6.0E-6 REAC_15=KL_41765(Ki_SPC__4, SPC_2178_, SPC_34_mi) # Reaction: id = REAC_16 # Local Parameter: id = Ki_SPC_27854_mitochondrion, name = Ki_3Azidotwo3dideoxythymidine par Ki_SPC__5=1.3E-4 REAC_16=KL_41764(SPC_2178_, SPC_34_mi, Ki_SPC__5) # Reaction: id = REAC_17 # Local Parameter: id = Ki_SPC_2178_mitochondrion, name = Ki_twoDeoxycytidine par Ki_SPC__6=6.7E-5 REAC_17=KL_41763(Ki_SPC__6, SPC_34_mi, SPC_2074_) # Reaction: id = REAC_18 # Local Parameter: id = Ki_SPC_1315_mitochondrion, name = Ki_Thymidine par Ki_SPC__7=2.0E-7 REAC_18=KL_41762(Ki_SPC__7, SPC_34_mi, SPC_2074_) # Reaction: id = REAC_19 # Local Parameter: id = Ki_SPC_13796_mitochondrion, name = Ki_5Fluorodeoxyuridine par Ki_SPC__8=2.0E-6 REAC_19=KL_41760(SPC_2074_, SPC_34_mi, Ki_SPC__8) # Reaction: id = REAC_20 # Local Parameter: id = Ki_SPC_27854_mitochondrion, name = Ki_3Azidotwo3dideoxythymidine par Ki_SPC__9=1.0E-6 REAC_20=KL_41761(SPC_2074_, SPC_34_mi, Ki_SPC__9) # Reaction: id = REAC_21 # Local Parameter: id = Km1_SPC_1315_mitochondrion, name = Km1_Thymidine par Km1_SPC_1=3.0E-7 # Local Parameter: id = Km2_SPC_1315_mitochondrion, name = Km2_Thymidine par Km2_SPC_1=1.6E-5 # Local Parameter: id = Vmax, name = Vmax par Vmax_1__6=9.333333E-6 # Local Parameter: id = n_SPC_1315_mitochondrion, name = n_Thymidine par n_SPC_131=0.5 # Local Parameter: id = Vmax_Km_SPC_1315_mitochondrion, name = Vmax_Km_Thymidine par Vmax_Km_1=31.1 REAC_21=KL_41745(Km1_SPC_1, SPC_34_mi, Km2_SPC_1, Vmax_1__6, n_SPC_131, Vmax_Km_1) # Reaction: id = REAC_22 # Local Parameter: id = Vmax_Km_SPC_2178_mitochondrion, name = Vmax_Km_twoDeoxycytidine par Vmax_Km_2=0.4166667 # Local Parameter: id = Vmax, name = Vmax par Vmax_1__7=1.5E-5 # Local Parameter: id = Km_SPC_2178_mitochondrion, name = Km_twoDeoxycytidine par Km_SPC__4=3.6E-5 REAC_22=KL_41746(Vmax_Km_2, SPC_2178_, Vmax_1__7, Km_SPC__4, SPC_34_mi) # Reaction: id = REAC_23 # Local Parameter: id = Vmax_Km_SPC_2074_mitochondrion, name = Vmax_Km_twoDeoxyuridine par Vmax_Km_3=1.916667 # Local Parameter: id = Vmax, name = Vmax par Vmax_1__8=1.15E-5 # Local Parameter: id = Km_SPC_2074_mitochondrion, name = Km_twoDeoxyuridine par Km_SPC_20=6.0E-6 REAC_23=KL_41747(SPC_34_mi, Vmax_Km_3, Vmax_1__8, Km_SPC_20, SPC_2074_) # Reaction: id = REAC_24 # Local Parameter: id = Km_SPC_13796_mitochondrion, name = Km_5Fluorodeoxyuridine par Km_SPC_13=7.0E-7 # Local Parameter: id = Vmax_Km_SPC_13796_mitochondrion, name = Vmax_Km_5Fluorodeoxyuridine par Vmax_Km_4=10.23333 # Local Parameter: id = Vmax, name = Vmax par Vmax_1__9=7.166667E-6 REAC_24=KL_41748(Km_SPC_13, SPC_13796, Vmax_Km_4, SPC_34_mi, Vmax_1__9) # Reaction: id = REAC_25 # Local Parameter: id = Ki_SPC_1678_mitochondrion, name = Ki_dCTP par Ki_SPC_16=2.0E-4 # Local Parameter: id = n_SPC_1678_mitochondrion, name = n_dCTP par n_SPC_167=0.6 REAC_25=KL_41768(SPC_1678_, Ki_SPC_16, SPC_1315_, n_SPC_167, SPC_34_mi) # Reaction: id = REAC_26 # Local Parameter: id = Ki_SPC_1679_mitochondrion, name = Ki_dTTP par Ki_SPC_10=7.0E-6 REAC_26=KL_41767(Ki_SPC_10, SPC_1315_, SPC_34_mi) # Reaction: id = REAC_27 # Local Parameter: id = Km_SPC_5404_Cell, name = Km_SAdenosylmethioninamine par Km_SPC_54=7.0E-6 REAC_27=KL_39577(SPC_5404_, Km_SPC_54, Vmax_1_10) # Reaction: id = REAC_28 # Local Parameter: id = Km_SPC_1941_Cell, name = Km_Putrescine par Km_SPC_19=8.0E-5 REAC_28=KL_39576(Vmax_1_11, SPC_1941_, Km_SPC_19) # Reaction: id = REAC_29 # Local Parameter: id = IC_50_SPC_5060_Cell, name = IC_50_Heparin par IC_50_SPC=2.083375E-5 REAC_29=KL_48160(SPC_23010, IC_50_SPC) # Reaction: id = REAC_30 # Local Parameter: id = IC_50_SPC_5060_Cell, name = IC_50_Heparin par IC_50_S_1=2.083375E-5 REAC_30=KL_48161(IC_50_S_1, SPC_23010) # Reaction: id = REAC_31 # Local Parameter: id = Km_SPC_23010_Cell, name = Km_4MethylumbelliferylbetaNacetylglucosaminide par Km_SPC_23=6.7E-4 REAC_31=KL_48158(Km_SPC_23, Vmax_1_12, SPC_23010) # Reaction: id = REAC_32 # Local Parameter: id = Km_SPC_23010_Cell, name = Km_4MethylumbelliferylbetaNacetylglucosaminide par Km_SPC__5=6.7E-4 REAC_32=KL_48159(Km_SPC__5, Vmax_1_13, SPC_23010) # Reaction: id = REAC_33 # Local Parameter: id = Km_SPC_21081_lysosome, name = Km_NDodecanoylsphingosine par Km_SPC__6=1.49E-4 # Local Parameter: id = Vmax, name = Vmax par Vmax_1_14=3.777778E-8 REAC_33=KL_21313(Km_SPC__6, SPC_21081, Vmax_1_14) # Reaction: id = REAC_34 # Local Parameter: id = EA, name = EA par EA=7.777778E-9 REAC_34=KL_21319(SPC_25141, EA) # Reaction: id = REAC_35 # Local Parameter: id = EA, name = EA par EA_1=5.277778E-9 REAC_35=KL_21316(SPC_25149, EA_1) # Reaction: id = REAC_36 # Local Parameter: id = EA, name = EA par EA_1_2=1.111111E-9 REAC_36=KL_21321(EA_1_2, SPC_25159) # Reaction: id = REAC_37 # Local Parameter: id = EA, name = EA par EA_1_2_3=2.972222E-8 REAC_37=KL_21314(SPC_21081, EA_1_2_3) # Reaction: id = REAC_38 # Local Parameter: id = EA, name = EA par EA_1_2__4=5.833333E-9 REAC_38=KL_21315(EA_1_2__4, SPC_25148) # Reaction: id = REAC_39 # Local Parameter: id = EA, name = EA par EA_1_2__5=8.333333E-9 REAC_39=KL_21317(EA_1_2__5, SPC_25150) # Reaction: id = REAC_40 # Local Parameter: id = EA, name = EA par EA_1_2__6=4.722222E-9 REAC_40=KL_21318(EA_1_2__6, SPC_25151) # Reaction: id = REAC_41 # Local Parameter: id = EA, name = EA par EA_1_2__7=8.333333E-10 REAC_41=KL_21320(EA_1_2__7, SPC_25130) # Species: id = SPC_2122_cytosol, name = Phosphatidylinositol, affected by kineticLaw par SPC_2122_=1.0 aux SPC_2122_=SPC_2122_ dSPC_2122_/dt=(1/(compart_c))*((-1.0 * REAC_0)) # Species: id = SPC_40_cytosol, name = H2O, affected by kineticLaw par SPC_40_cy=1.0 aux SPC_40_cy=SPC_40_cy dSPC_40_cy/dt=(1/(compart_c))*((-1.0 * REAC_0)) # Species: id = SPC_5013_cytosol, name = Diacylglycerol, affected by kineticLaw par SPC_5013_=1.0 aux SPC_5013_=SPC_5013_ dSPC_5013_/dt=(1/(compart_c))*(( 1.0 * REAC_0)) # Species: id = SPC_5422_cytosol, name = 1D-myo-Inositol 1-phosphate, affected by kineticLaw par SPC_5422_=1.0 aux SPC_5422_=SPC_5422_ dSPC_5422_/dt=(1/(compart_c))*(( 1.0 * REAC_0)) # Species: id = ENZ_225573_cytosol, name = phosphoinositide phospholipase C(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_22557=1.0 aux ENZ_22557=ENZ_22557 # Species: id = SPC_2122_membrane, name = Phosphatidylinositol, affected by kineticLaw par SPC_212_1=1.0 aux SPC_212_1=SPC_212_1 dSPC_212_1/dt=(1/(compart_m))*((-1.0 * REAC_1)) # Species: id = SPC_40_membrane, name = H2O, affected by kineticLaw par SPC_40_me=1.0 aux SPC_40_me=SPC_40_me dSPC_40_me/dt=(1/(compart_m))*((-1.0 * REAC_1)) # Species: id = SPC_5013_membrane, name = Diacylglycerol, affected by kineticLaw par SPC_501_1=1.0 aux SPC_501_1=SPC_501_1 dSPC_501_1/dt=(1/(compart_m))*(( 1.0 * REAC_1)) # Species: id = SPC_5422_membrane, name = 1D-myo-Inositol 1-phosphate, affected by kineticLaw par SPC_542_1=1.0 aux SPC_542_1=SPC_542_1 dSPC_542_1/dt=(1/(compart_m))*(( 1.0 * REAC_1)) # Species: id = ENZ_225568_membrane, name = phosphoinositide phospholipase C(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_22556=1.0 aux ENZ_22556=ENZ_22556 # Species: id = SPC_40_lysosome, name = H2O, affected by kineticLaw par SPC_40_ly=1.0 aux SPC_40_ly=SPC_40_ly dSPC_40_ly/dt=(1/(compart_l))*((-1.0 * REAC_2) + (-1.0 * REAC_33) + (-1.0 * REAC_34) + (-1.0 * REAC_35) + (-1.0 * REAC_36) + (-1.0 * REAC_37) + (-1.0 * REAC_38) + (-1.0 * REAC_39) + (-1.0 * REAC_40) + (-1.0 * REAC_41)) # Species: id = SPC_28371_lysosome, name = 4-Methylumbelliferyl-alpha-D-galactoside, affected by kineticLaw par SPC_28371=1.0 aux SPC_28371=SPC_28371 dSPC_28371/dt=(1/(compart_l))*((-1.0 * REAC_2)) # Species: id = SPC_90_lysosome, name = alpha-D-Galactose, affected by kineticLaw par SPC_90_ly=1.0 aux SPC_90_ly=SPC_90_ly dSPC_90_ly/dt=(1/(compart_l))*(( 1.0 * REAC_2)) # Species: id = SPC_6439_lysosome, name = 4-Methylumbelliferone, affected by kineticLaw par SPC_6439_=1.0 aux SPC_6439_=SPC_6439_ dSPC_6439_/dt=(1/(compart_l))*(( 1.0 * REAC_2)) # Species: id = ENZ_286858_lysosome, name = alpha-galactosidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_28685=1.0 aux ENZ_28685=ENZ_28685 # Species: id = SPC_1315_mitochondrion, name = Thymidine, affected by kineticLaw par SPC_1315_=1.0 aux SPC_1315_=SPC_1315_ dSPC_1315_/dt=(1/(compart_1))*((-1.0 * REAC_3) + (-1.0 * REAC_4) + (-1.0 * REAC_5) + (-1.0 * REAC_6) + (-1.0 * REAC_7) + (-1.0 * REAC_9) + (-1.0 * REAC_12) + (-1.0 * REAC_13) + (-1.0 * REAC_21) + (-1.0 * REAC_25) + (-1.0 * REAC_26)) # Species: id = SPC_34_mitochondrion, name = ATP, affected by kineticLaw par SPC_34_mi=1.0 aux SPC_34_mi=SPC_34_mi dSPC_34_mi/dt=(1/(compart_1))*((-1.0 * REAC_3) + (-1.0 * REAC_4) + (-1.0 * REAC_5) + (-1.0 * REAC_6) + (-1.0 * REAC_7) + (-1.0 * REAC_8) + (-1.0 * REAC_10) + (-1.0 * REAC_12) + (-1.0 * REAC_13) + (-1.0 * REAC_14) + (-1.0 * REAC_15) + (-1.0 * REAC_16) + (-1.0 * REAC_17) + (-1.0 * REAC_18) + (-1.0 * REAC_19) + (-1.0 * REAC_20) + (-1.0 * REAC_21) + (-1.0 * REAC_22) + (-1.0 * REAC_23) + (-1.0 * REAC_24) + (-1.0 * REAC_25) + (-1.0 * REAC_26)) # Species: id = SPC_65_mitochondrion, name = dTMP, affected by kineticLaw par SPC_65_mi=1.0 aux SPC_65_mi=SPC_65_mi dSPC_65_mi/dt=(1/(compart_1))*(( 1.0 * REAC_3) + ( 1.0 * REAC_4) + ( 1.0 * REAC_5) + ( 1.0 * REAC_6) + ( 1.0 * REAC_7) + ( 1.0 * REAC_9) + ( 1.0 * REAC_12) + ( 1.0 * REAC_13) + ( 1.0 * REAC_21) + ( 1.0 * REAC_25) + ( 1.0 * REAC_26)) # Species: id = SPC_35_mitochondrion, name = ADP, affected by kineticLaw par SPC_35_mi=1.0 aux SPC_35_mi=SPC_35_mi dSPC_35_mi/dt=(1/(compart_1))*(( 1.0 * REAC_3) + ( 1.0 * REAC_4) + ( 1.0 * REAC_5) + ( 1.0 * REAC_6) + ( 1.0 * REAC_7) + ( 1.0 * REAC_8) + ( 1.0 * REAC_10) + ( 1.0 * REAC_12) + ( 1.0 * REAC_13) + ( 1.0 * REAC_14) + ( 1.0 * REAC_15) + ( 1.0 * REAC_16) + ( 1.0 * REAC_17) + ( 1.0 * REAC_18) + ( 1.0 * REAC_19) + ( 1.0 * REAC_20) + ( 1.0 * REAC_21) + ( 1.0 * REAC_22) + ( 1.0 * REAC_23) + ( 1.0 * REAC_24) + ( 1.0 * REAC_25) + ( 1.0 * REAC_26)) # Species: id = SPC_27857_mitochondrion, name = 2',3'-Didehydro-2',3'-dideoxythymidine # Warning species is not changed by either rules or reactions par SPC_27857=1.0 aux SPC_27857=SPC_27857 # Species: id = ENZ_236178_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23617=1.0 aux ENZ_23617=ENZ_23617 # Species: id = SPC_13796_mitochondrion, name = 5-Fluorodeoxyuridine, affected by kineticLaw par SPC_13796=1.0 aux SPC_13796=SPC_13796 dSPC_13796/dt=(1/(compart_1))*((-1.0 * REAC_24)) # Species: id = ENZ_236184_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23618=1.0 aux ENZ_23618=ENZ_23618 # Species: id = SPC_27854_mitochondrion, name = 3'-Azido-2',3'-dideoxythymidine, affected by kineticLaw par SPC_27854=1.0 aux SPC_27854=SPC_27854 dSPC_27854/dt=(1/(compart_1))*((-1.0 * REAC_10)) # Species: id = ENZ_236166_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23616=1.0 aux ENZ_23616=ENZ_23616 # Species: id = SPC_27856_mitochondrion, name = 3'-Fluoro-2',3'-dideoxythymidine # Warning species is not changed by either rules or reactions par SPC_27856=1.0 aux SPC_27856=SPC_27856 # Species: id = ENZ_236172_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_1=1.0 aux ENZ_236_1=ENZ_236_1 # Species: id = ENZ_236145_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23614=1.0 aux ENZ_23614=ENZ_23614 # Species: id = SPC_2178_mitochondrion, name = 2'-Deoxycytidine, affected by kineticLaw par SPC_2178_=1.0 aux SPC_2178_=SPC_2178_ dSPC_2178_/dt=(1/(compart_1))*((-1.0 * REAC_8) + (-1.0 * REAC_11) + (-1.0 * REAC_14) + (-1.0 * REAC_15) + (-1.0 * REAC_16) + (-1.0 * REAC_22)) # Species: id = SPC_63_mitochondrion, name = dCMP, affected by kineticLaw par SPC_63_mi=1.0 aux SPC_63_mi=SPC_63_mi dSPC_63_mi/dt=(1/(compart_1))*(( 1.0 * REAC_8) + ( 1.0 * REAC_11) + ( 1.0 * REAC_14) + ( 1.0 * REAC_15) + ( 1.0 * REAC_16) + ( 1.0 * REAC_22)) # Species: id = ENZ_236155_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23615=1.0 aux ENZ_23615=ENZ_23615 # Species: id = SPC_1286_mitochondrion, name = CTP, affected by kineticLaw par SPC_1286_=1.0 aux SPC_1286_=SPC_1286_ dSPC_1286_/dt=(1/(compart_1))*((-1.0 * REAC_9) + (-1.0 * REAC_11)) # Species: id = SPC_1302_mitochondrion, name = CDP, affected by kineticLaw par SPC_1302_=1.0 aux SPC_1302_=SPC_1302_ dSPC_1302_/dt=(1/(compart_1))*(( 1.0 * REAC_9) + ( 1.0 * REAC_11)) # Species: id = ENZ_236150_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_2=1.0 aux ENZ_236_2=ENZ_236_2 # Species: id = SPC_27853_mitochondrion, name = 3'-Azido-2',3'-dideoxythymidine 5'-phosphate, affected by kineticLaw par SPC_27853=1.0 aux SPC_27853=SPC_27853 dSPC_27853/dt=(1/(compart_1))*(( 1.0 * REAC_10)) # Species: id = ENZ_236140_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_3=1.0 aux ENZ_236_3=ENZ_236_3 # Species: id = ENZ_236160_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_4=1.0 aux ENZ_236_4=ENZ_236_4 # Species: id = SPC_2074_mitochondrion, name = 2'-Deoxyuridine, affected by kineticLaw par SPC_2074_=1.0 aux SPC_2074_=SPC_2074_ dSPC_2074_/dt=(1/(compart_1))*((-1.0 * REAC_17) + (-1.0 * REAC_18) + (-1.0 * REAC_19) + (-1.0 * REAC_20) + (-1.0 * REAC_23)) # Species: id = ENZ_236190_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23619=1.0 aux ENZ_23619=ENZ_23619 # Species: id = ENZ_236196_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_5=1.0 aux ENZ_236_5=ENZ_236_5 # Species: id = ENZ_236238_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23623=1.0 aux ENZ_23623=ENZ_23623 # Species: id = ENZ_236232_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_6=1.0 aux ENZ_236_6=ENZ_236_6 # Species: id = ENZ_236226_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23622=1.0 aux ENZ_23622=ENZ_23622 # Species: id = SPC_1334_mitochondrion, name = dUMP, affected by kineticLaw par SPC_1334_=1.0 aux SPC_1334_=SPC_1334_ dSPC_1334_/dt=(1/(compart_1))*(( 1.0 * REAC_17) + ( 1.0 * REAC_18) + ( 1.0 * REAC_19) + ( 1.0 * REAC_20) + ( 1.0 * REAC_23)) # Species: id = ENZ_236220_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_7=1.0 aux ENZ_236_7=ENZ_236_7 # Species: id = ENZ_236214_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23621=1.0 aux ENZ_23621=ENZ_23621 # Species: id = ENZ_236202_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23620=1.0 aux ENZ_23620=ENZ_23620 # Species: id = ENZ_236208_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_8=1.0 aux ENZ_236_8=ENZ_236_8 # Species: id = ENZ_236120_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23612=1.0 aux ENZ_23612=ENZ_23612 # Species: id = ENZ_236125_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_236_9=1.0 aux ENZ_236_9=ENZ_236_9 # Species: id = ENZ_236130_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23613=1.0 aux ENZ_23613=ENZ_23613 # Species: id = SPC_27852_mitochondrion, name = 5-Fluorodeoxyuridine 5'-phosphate, affected by kineticLaw par SPC_27852=1.0 aux SPC_27852=SPC_27852 dSPC_27852/dt=(1/(compart_1))*(( 1.0 * REAC_24)) # Species: id = ENZ_236135_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23_10=1.0 aux ENZ_23_10=ENZ_23_10 # Species: id = SPC_1678_mitochondrion, name = dCTP # Warning species is not changed by either rules or reactions par SPC_1678_=1.0 aux SPC_1678_=SPC_1678_ # Species: id = ENZ_236250_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23625=1.0 aux ENZ_23625=ENZ_23625 # Species: id = SPC_1679_mitochondrion, name = dTTP # Warning species is not changed by either rules or reactions par SPC_1679_=1.0 aux SPC_1679_=SPC_1679_ # Species: id = ENZ_236244_mitochondrion, name = thymidine kinase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_23624=1.0 aux ENZ_23624=ENZ_23624 # Species: id = SPC_5404_Cell, name = S-Adenosylmethioninamine, affected by kineticLaw par SPC_5404_=1.0 aux SPC_5404_=SPC_5404_ dSPC_5404_/dt=(1/(compart_2))*((-1.0 * REAC_27) + (-1.0 * REAC_28)) # Species: id = SPC_1941_Cell, name = Putrescine, affected by kineticLaw par SPC_1941_=1.0 aux SPC_1941_=SPC_1941_ dSPC_1941_/dt=(1/(compart_2))*((-1.0 * REAC_27) + (-1.0 * REAC_28)) # Species: id = SPC_3088_Cell, name = Spermidine, affected by kineticLaw par SPC_3088_=1.0 aux SPC_3088_=SPC_3088_ dSPC_3088_/dt=(1/(compart_2))*(( 1.0 * REAC_27) + ( 1.0 * REAC_28)) # Species: id = SPC_1960_Cell, name = 5'-Deoxy-5'-(methylthio)adenosine, affected by kineticLaw par SPC_1960_=1.0 aux SPC_1960_=SPC_1960_ dSPC_1960_/dt=(1/(compart_2))*(( 1.0 * REAC_27) + ( 1.0 * REAC_28)) # Species: id = ENZ_224044_Cell, name = spermidine synthase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_22404=1.0 aux ENZ_22404=ENZ_22404 # Species: id = ENZ_224039_Cell, name = spermidine synthase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_22403=1.0 aux ENZ_22403=ENZ_22403 # Species: id = SPC_40_Cell, name = H2O, affected by kineticLaw par SPC_40_Ce=1.0 aux SPC_40_Ce=SPC_40_Ce dSPC_40_Ce/dt=(1/(compart_2))*((-1.0 * REAC_29) + (-1.0 * REAC_30) + (-1.0 * REAC_31) + (-1.0 * REAC_32)) # Species: id = SPC_23010_Cell, name = 4-Methylumbelliferyl-beta-N-acetylglucosaminide, affected by kineticLaw par SPC_23010=1.0 aux SPC_23010=SPC_23010 dSPC_23010/dt=(1/(compart_2))*((-1.0 * REAC_29) + (-1.0 * REAC_30) + (-1.0 * REAC_31) + (-1.0 * REAC_32)) # Species: id = SPC_6916_Cell, name = N-Acetyl-beta-D-glucosamine, affected by kineticLaw par SPC_6916_=1.0 aux SPC_6916_=SPC_6916_ dSPC_6916_/dt=(1/(compart_2))*(( 1.0 * REAC_29) + ( 1.0 * REAC_30) + ( 1.0 * REAC_31) + ( 1.0 * REAC_32)) # Species: id = SPC_6439_Cell, name = 4-Methylumbelliferone, affected by kineticLaw par SPC_643_1=1.0 aux SPC_643_1=SPC_643_1 dSPC_643_1/dt=(1/(compart_2))*(( 1.0 * REAC_29) + ( 1.0 * REAC_30) + ( 1.0 * REAC_31) + ( 1.0 * REAC_32)) # Species: id = SPC_5060_Cell, name = Heparin # Warning species is not changed by either rules or reactions par SPC_5060_=1.0 aux SPC_5060_=SPC_5060_ # Species: id = ENZ_273848_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A # Warning species is not changed by either rules or reactions par ENZ_27384=1.0 aux ENZ_27384=ENZ_27384 # Species: id = ENZ_273854_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B # Warning species is not changed by either rules or reactions par ENZ_27385=1.0 aux ENZ_27385=ENZ_27385 # Species: id = ENZ_273837_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform A # Warning species is not changed by either rules or reactions par ENZ_27383=1.0 aux ENZ_27383=ENZ_27383 # Species: id = ENZ_273842_Cell, name = beta-N-acetylhexosaminidase(Enzyme) wildtype isoform B # Warning species is not changed by either rules or reactions par ENZ_273_1=1.0 aux ENZ_273_1=ENZ_273_1 # Species: id = SPC_21081_lysosome, name = N-Dodecanoylsphingosine, affected by kineticLaw par SPC_21081=1.0 aux SPC_21081=SPC_21081 dSPC_21081/dt=(1/(compart_l))*((-1.0 * REAC_33) + (-1.0 * REAC_37)) # Species: id = SPC_5042_lysosome, name = Sphingosine, affected by kineticLaw par SPC_5042_=1.0 aux SPC_5042_=SPC_5042_ dSPC_5042_/dt=(1/(compart_l))*(( 1.0 * REAC_33) + ( 1.0 * REAC_34) + ( 1.0 * REAC_35) + ( 1.0 * REAC_37) + ( 1.0 * REAC_38) + ( 1.0 * REAC_39) + ( 1.0 * REAC_40)) # Species: id = SPC_2488_lysosome, name = Dodecanoate, affected by kineticLaw par SPC_2488_=1.0 aux SPC_2488_=SPC_2488_ dSPC_2488_/dt=(1/(compart_l))*(( 1.0 * REAC_33) + ( 1.0 * REAC_37)) # Species: id = ENZ_112389_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_11238=1.0 aux ENZ_11238=ENZ_11238 # Species: id = SPC_25141_lysosome, name = N-Oleoyl-D-sphingosine, affected by kineticLaw par SPC_25141=1.0 aux SPC_25141=SPC_25141 dSPC_25141/dt=(1/(compart_l))*((-1.0 * REAC_34)) # Species: id = SPC_2139_lysosome, name = Oleate, affected by kineticLaw par SPC_2139_=1.0 aux SPC_2139_=SPC_2139_ dSPC_2139_/dt=(1/(compart_l))*(( 1.0 * REAC_34)) # Species: id = ENZ_112419_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_11241=1.0 aux ENZ_11241=ENZ_11241 # Species: id = SPC_25149_lysosome, name = N-Hexanoyl-D-erythro-sphingosine, affected by kineticLaw par SPC_25149=1.0 aux SPC_25149=SPC_25149 dSPC_25149/dt=(1/(compart_l))*((-1.0 * REAC_35)) # Species: id = SPC_2297_lysosome, name = Hexanoate, affected by kineticLaw par SPC_2297_=1.0 aux SPC_2297_=SPC_2297_ dSPC_2297_/dt=(1/(compart_l))*(( 1.0 * REAC_35)) # Species: id = ENZ_112404_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_11240=1.0 aux ENZ_11240=ENZ_11240 # Species: id = SPC_25159_lysosome, name = N-Palmitoylsphinganine, affected by kineticLaw par SPC_25159=1.0 aux SPC_25159=SPC_25159 dSPC_25159/dt=(1/(compart_l))*((-1.0 * REAC_36)) # Species: id = SPC_1990_lysosome, name = Palmitate, affected by kineticLaw par SPC_1990_=1.0 aux SPC_1990_=SPC_1990_ dSPC_1990_/dt=(1/(compart_l))*(( 1.0 * REAC_36)) # Species: id = SPC_5264_lysosome, name = Sphinganine, affected by kineticLaw par SPC_5264_=1.0 aux SPC_5264_=SPC_5264_ dSPC_5264_/dt=(1/(compart_l))*(( 1.0 * REAC_36) + ( 1.0 * REAC_41)) # Species: id = ENZ_112429_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_11242=1.0 aux ENZ_11242=ENZ_11242 # Species: id = ENZ_112394_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_11239=1.0 aux ENZ_11239=ENZ_11239 # Species: id = SPC_25148_lysosome, name = N-Acetyl-D-sphingosine, affected by kineticLaw par SPC_25148=1.0 aux SPC_25148=SPC_25148 dSPC_25148/dt=(1/(compart_l))*((-1.0 * REAC_38)) # Species: id = SPC_1278_lysosome, name = Acetate, affected by kineticLaw par SPC_1278_=1.0 aux SPC_1278_=SPC_1278_ dSPC_1278_/dt=(1/(compart_l))*(( 1.0 * REAC_38)) # Species: id = ENZ_112399_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_112_1=1.0 aux ENZ_112_1=ENZ_112_1 # Species: id = SPC_25150_lysosome, name = N-Octanoyl-D-sphingosine, affected by kineticLaw par SPC_25150=1.0 aux SPC_25150=SPC_25150 dSPC_25150/dt=(1/(compart_l))*((-1.0 * REAC_39)) # Species: id = SPC_2889_lysosome, name = Octanoate, affected by kineticLaw par SPC_2889_=1.0 aux SPC_2889_=SPC_2889_ dSPC_2889_/dt=(1/(compart_l))*(( 1.0 * REAC_39) + ( 1.0 * REAC_41)) # Species: id = ENZ_112409_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_112_2=1.0 aux ENZ_112_2=ENZ_112_2 # Species: id = SPC_25151_lysosome, name = N-Stearoyl-D-sphingosine, affected by kineticLaw par SPC_25151=1.0 aux SPC_25151=SPC_25151 dSPC_25151/dt=(1/(compart_l))*((-1.0 * REAC_40)) # Species: id = SPC_20032_lysosome, name = Stearate, affected by kineticLaw par SPC_20032=1.0 aux SPC_20032=SPC_20032 dSPC_20032/dt=(1/(compart_l))*(( 1.0 * REAC_40)) # Species: id = ENZ_112414_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_112_3=1.0 aux ENZ_112_3=ENZ_112_3 # Species: id = SPC_25130_lysosome, name = N-Octanoylsphinganine, affected by kineticLaw par SPC_25130=1.0 aux SPC_25130=SPC_25130 dSPC_25130/dt=(1/(compart_l))*((-1.0 * REAC_41)) # Species: id = ENZ_112424_lysosome, name = ceramidase(Enzyme) wildtype # Warning species is not changed by either rules or reactions par ENZ_112_4=1.0 aux ENZ_112_4=ENZ_112_4 @ meth=cvode, tol=1e-6, atol=1e-8 # @ maxstor=1e6 @ bound=40000, total=200 done