Enzyme Details

EC Classification

1.1.1.210

Enzyme name
(recommended)

3beta(or 20alpha)-hydroxysteroid dehydrogenase

Alternative names

3beta(or 20alpha)-hydroxysteroid:NADP+ oxidoreductase
progesterone reductase
dehydrogenase, 3beta,20alpha-hydroxy steroid
3beta,20alpha-hydroxysteroid oxidoreductase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstan-3beta,17beta-diol

NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + Epiandrosterone <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + 3beta-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone

NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione

NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone

H+ + NADPH + 5beta-Androstane-17beta-ol-3-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.210