Enzyme Details

EC Classification

1.1.1.239

Enzyme name
(recommended)

3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Alternative names

3alpha(or 17beta)-hydroxysteroid:NAD+ oxidoreductase
3alpha,17beta-hydroxy steroid dehydrogenase
3alpha(17beta)-HSD
3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione

NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone

NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + 5beta-Androstane-3alpha,17beta-diol <-> NADH + H+ + 3alpha-Hydroxy-5beta-androstan-17-one

NAD+ + 5alpha-Androstane-3alpha,17beta-diol <-> NADH + H+ + 5alpha-Androstan-3alpha-ol-17-one

NAD+ + 5beta-Androstane-17beta-ol-3-one <-> NADH + H+ + 5beta-Androstane-3,17-dione

NADH + H+ + Estrone 3-sulfate <-> NAD+ + Estradiol-17beta 3-sulfate

H+ + NADPH + 5alpha-Androstane-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione

NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.239