Enzyme Details

EC Classification

1.1.1.28

Enzyme name
(recommended)

D-lactate dehydrogenase

Alternative names

(R)-lactate:NAD+ oxidoreductase
lactic acid dehydrogenase
lactic acid dehydrogenase
D-specific lactic dehydrogenase
D-(-)-lactate dehydrogenase (NAD+)
D-lactic acid dehydrogenase
D-lactic dehydrogenase

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + L-Lactate <-> Pyruvate + NADH + H+

NAD+ + D-Lactate <-> Pyruvate + NADH + H+

NAD+ + 2-Hydroxybutyrate <-> NADH + H+ + 2-Oxobutyrate

NADP+ + Phenyllactate <-> H+ + NADPH + Phenylpyruvate

H+ + NADPH + 2-Oxobutyrate <-> NADP+ + D-2-Hydroxybutyrate

Pyruvate + H+ + NADPH <-> NADP+ + D-Lactate

Pyruvate + H+ + Deamino-NADH <-> Deamino-NAD+ + D-Lactate

D-Lactate + 3-Acetylpyridine-adenine dinucleotide <-> Pyruvate + H+ + Reduced 3-acetylpyridine-adenine dinucleotide

NADH + H+ + 3-Hydroxypyruvate <-> NAD+ + Glycerate

NAD+ + Phenyllactate <-> NADH + H+ + Phenylpyruvate

NADH + H+ + 2-Oxopentanoate <-> NAD+ + 2-Hydroxyvalerate

NADH + H+ + alpha-Ketovaline <-> NAD+ + 2-Hydroxyisovalerate

NADH + H+ + 2-Oxohexanoate <-> NAD+ + 2-Hydroxycaproate

NADH + H+ + 4-Methyl-2-oxopentanoate <-> NAD+ + 2-Hydroxyisocaproate

NADH + H+ + 3-Bromopyruvate <-> NAD+ + 3-Bromolactate

NAD+ + D-Malate <-> NADH + H+ + Oxaloacetate

NAD+ + Glycolate <-> NADH + H+ + Glyoxylate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.28