Enzyme Details
EC Classification
1.1.1.357
Enzyme name
(recommended)
3alpha-hydroxysteroid 3-dehydrogenase
Alternative names
3alpha-hydroxysteroid dehydrogenase
Classification
Oxidoreductases
Acting on the CH-OH group of donors
With NAD(+) or NADP(+) as acceptor
Catalyses reactions
NAD+ + Androstanediol <-> NADH + H+ + 5alpha-Androstane-17beta-ol-3-one
NADP+ + 3alpha-Hydroxy-5alpha-pregnan-20-one <-> H+ + NADPH + 5alpha-Pregnane-3,20-dione
NAD+ + 5alpha-Androstane-3alpha-ol-17-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NAD+ + 3beta-Hydroxy-5beta-androstan-17-one <-> NADH + H+ + 5beta-Androstane-3,17-dione
NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione
NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone
NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione
NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone
NAD+ + Epiandrosterone <-> NADH + H+ + 5alpha-Androstane-3,17-dione
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol
NADP+ + Pregnanediol <-> H+ + NADPH + 3alpha-Hydroxy-5beta-pregnane-20-one
H+ + NADPH + 5alpha-Androstane-17beta-ol-3-one <-> NADP+ + Androstanediol
NADP+ + 5alpha-Pregnan-3alpha,20alpha-diol <-> H+ + NADPH + 20alpha-Hydroxy-5alpha-pregnan-3-one
H+ + NADPH + 20alpha-Hydroxy-5beta-pregnan-3-one <-> NADP+ + Pregnanediol
NADP+ + 3alpha-Hydroxy-5beta-pregnane-20-one <-> H+ + NADPH + 5beta-Pregnane-3,20-dione
NADP+ + 5alpha-Pregnan-3alpha,21-diol-20-one <-> H+ + NADPH + 5alpha-Pregnane-21-ol-3,20-dione
External links
Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop
View all entries for EC Class:
1.1.1.357
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