Enzyme Details

EC Classification

1.1.1.62

Enzyme name
(recommended)

estradiol 17beta-dehydrogenase

Alternative names

estradiol-17beta:NAD(P)+ 17-oxidoreductase
20alpha-hydroxysteroid dehydrogenase
17beta,20alpha-hydroxysteroid dehydrogenase
17beta-estradiol dehydrogenase
estradiol dehydrogenase
estrogen 17-oxidoreductase
17beta-HSD

Classification

Oxidoreductases

Acting on the CH-OH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NAD+ + Testosterone <-> NADH + H+ + Androst-4-ene-3,17-dione

NADP+ + Testosterone <-> H+ + NADPH + Androst-4-ene-3,17-dione

NADP+ + 20alpha-Hydroxy-4-pregnen-3-one <-> H+ + NADPH + Progesterone

NAD+ + Estradiol-17beta <-> NADH + H+ + Estrone

NADP+ + Estradiol-17beta <-> H+ + NADPH + Estrone

NADP+ + 17alpha,20alpha-Dihydroxypregn-4-en-3-one <-> H+ + NADPH + 17alpha-Hydroxyprogesterone

NADP+ + Androst-5-ene-3beta,17beta-diol <-> H+ + NADPH + 3beta-Hydroxyandrost-5-en-17-one

NAD+ + Estriol <-> NADH + H+ + 16alpha-Hydroxyestrone

NADP+ + Estriol <-> H+ + NADPH + 16alpha-Hydroxyestrone

H+ + NADPH + p-Nitrobenzaldehyde <-> NADP+ + p-Nitrobenzyl alcohol

H+ + NADPH + Prostaglandin D2 <-> NADP+ + 9alpha,11beta-Prostaglandin F2

H+ + NADPH + 9,10-Phenanthroquinone <-> NADP+ + Phenanthrene-9,10-diol

NADP+ + (S)-Indan-1-ol <-> H+ + NADPH + Indanone

H+ + NADPH + 4-Nitroacetophenone <-> NADP+ + 1-(4-Nitrophenyl)ethanol

NADP+ + Cyclohex-2-en-1-ol <-> H+ + NADPH + Cyclohex-2-enone

H+ + NADPH + 5beta-Pregnane-3,20-dione <-> NADP+ + 20alpha-Hydroxy-5beta-pregnan-3-one

H+ + NADPH + 4-Chlorobenzaldehyde <-> NADP+ + p-Chlorobenzyl alcohol

H+ + NADPH + Isatin <-> NADP+ + 2,3-Dihydroxyindole

H+ + NADPH + 16-Ketoestrone <-> NADP+ + 16-Hydroxyestrone

H+ + NADPH + 21-Dehydrocortisol <-> NADP+ + Cortisol

H+ + NADPH + 5alpha-Androstane-3alpha-ol-17-one <-> NADP+ + 5alpha-Androstane-3alpha,17beta-diol

H+ + NADPH + 3alpha-Hydroxy-5beta-androstan-17-one <-> NADP+ + 5beta-Androstane-3alpha,17beta-diol

NADP+ + 5beta-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5beta-Androstane-3,17-dione

NADP+ + 5alpha-Androstane-17beta-ol-3-one <-> H+ + NADPH + 5alpha-Androstane-3,17-dione

H+ + NADPH + 6-tert-Butyl-2,3-epoxy-5-cyclohexene-1,4-dione <-> NADP+ + 6-tert-Butyl-2,3-epoxy-4-hydroxy-5-cyclohexene-1-one

NADP+ + (S)-(+)-1,2,3,4-Tetrahydro-1-naphthol <-> H+ + NADPH + (S)-(+)-2,3,4-Trihydro-1-naphtone

2 NADH + 2 H+ + (1R)-(-)-Camphorquinone <-> 2 NAD+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

2 NADP+ + trans-Cyclohexa-3,5-diene-1,2-diol <-> 2 H+ + 2 NADPH + 2-Hydroxycyclohexa-3,5-diene-1-one

NADP+ + 3alpha-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital

NADP+ + beta-3-Hydroxyhexobarbital <-> H+ + NADPH + 3-Oxohexobarbital

NADP+ + 9alpha,11alpha-Prostaglandin F2 <-> H+ + NADPH + Prostaglandin D2

2 H+ + 2 NADPH + (1S)-(+)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

2 H+ + 2 NADPH + (1R)-(-)-Camphorquinone <-> 2 NADP+ + 1,7,7-trimethylbicyclo[2.2.1]heptane-2,3-diol

2 H+ + 2 NADPH + 2,3-Pentanedione <-> 2 NADP+ + 2,3-Pentanediol

2 H+ + 2 NADPH + Dimethylglyoxal <-> 2 NADP+ + 2,3-Butanediol

H+ + NADPH + 2-Acetylpyridine <-> NADP+ + 1-(Pyridin-2-yl)ethanol

H+ + NADPH + 4-Androsten-3alpha-ol-17-one <-> NADP+ + Androst-4-ene-3alpha,17beta-diol

NAD+ + 5alpha-Androstane-17beta-ol-3-one <-> NADH + H+ + 5alpha-Androstane-3,17-dione

NAD+ + 20alpha-Hydroxy-4-pregnen-3-one <-> NADH + H+ + Progesterone

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.1.1.62