Enzyme Details

EC Classification

1.14.14.17

Enzyme name
(recommended)

squalene monooxygenase

Alternative names

squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing)
squalene epoxidase
squalene-2,3-epoxide cyclase
squalene 2,3-oxidocyclase
squalene hydroxylase
squalene oxydocyclase
squalene-2,3-epoxidase

Classification

Oxidoreductases

Acting on paired donors with incorporation of molecular oxygen

With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

Catalyses reactions

O2 + Reduced acceptor + Squalene <-> H2O + Acceptor + (S)-2,3-Epoxysqualene

H+ + NADPH + O2 + Squalene <-> H2O + NADP+ + (S)-2,3-Epoxysqualene

H+ + NADPH + O2 + (S)-2,3-Epoxysqualene <-> H2O + NADP+ + Diepoxysqualene

NADH + H+ + O2 + Squalene <-> NAD+ + H2O + (S)-2,3-Epoxysqualene

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.14.14.17