Enzyme Details

EC Classification

1.2.4.2

Enzyme name
(recommended)

oxoglutarate dehydrogenase (succinyl-transferring)

Alternative names

2-oxoglutarate:[dihydrolipoyllysine-residue succinyltransferase]-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)
2-ketoglutarate dehydrogenase
2-oxoglutarate dehydrogenase
2-oxoglutarate: lipoate oxidoreductase
2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating)
alpha-ketoglutarate dehydrogenase
alphaketoglutaric acid dehydrogenase
alpha-ketoglutaric dehydrogenase
alpha-oxoglutarate dehydrogenase
AKGDH
OGDC
ketoglutaric dehydrogenase
oxoglutarate decarboxylase
oxoglutarate dehydrogenase
oxoglutarate dehydrogenase (lipoamide)

Classification

Oxidoreductases

Acting on the aldehyde or oxo group of donors

With a disulfide as acceptor

Catalyses reactions

Thiamine diphosphate + 2-Oxoglutarate <-> CO2 + 3-Carboxy-1-hydroxypropyl-ThPP

Lipoamide + 3-Carboxy-1-hydroxypropyl-ThPP <-> Thiamine diphosphate + S-Succinyldihydrolipoamide

Lipoamide + 2-Oxoglutarate <-> CO2 + S-Succinyldihydrolipoamide

NAD+ + Coenzyme A + 2-Oxoadipate <-> NADH + H+ + CO2 + Glutaryl-CoA

Lipoamide + 2-Oxoadipate <-> CO2 + S-Glutaryldihydrolipoamide

NAD+ + Coenzyme A + 2-Oxoglutarate <-> NADH + H+ + CO2 + Succinyl-CoA

H2O + 2-Oxoglutarate + Hexacyanoferrate(III) <-> CO2 + Succinate + Hexacyanoferrate(II)

2-Oxoglutarate + 2,6-Dichloroindophenol <-> CO2 + Succinate semialdehyde + Reduced 2,6-dichlorophenolindophenol

NADP+ + Coenzyme A + 2-Oxoglutarate <-> H+ + NADPH + CO2 + Succinyl-CoA

H2O + 2-Oxoglutarate + 2 Hexacyanoferrate(III) <-> 2 H+ + CO2 + Succinate + 2 Hexacyanoferrate(II)

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.2.4.2