Enzyme Details

EC Classification

1.5.1.5

Enzyme name
(recommended)

methylenetetrahydrofolate dehydrogenase (NADP+)

Alternative names

5,10-methylenetetrahydrofolate:NADP+ oxidoreductase
N5,N10-methylenetetrahydrofolate dehydrogenase
5,10-methylenetetrahydrofolate:NADP oxidoreductase
5,10-methylenetetrahydrofolate dehydrogenase
methylenetetrahydrofolate dehydrogenase
methylenetetrahydrofolate dehydrogenase (NADP)

Classification

Oxidoreductases

Acting on the CH-NH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + 5,10-Methylenetetrahydrofolate <-> H+ + NADPH + 5,10-Methenyltetrahydrofolate

NAD+ + 5,10-Methylenetetrahydrofolate <-> NADH + H+ + 5,10-Methenyltetrahydrofolate

NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.5.1.5