Reaction Details
Reaction ID
100
Stochiometric Equation
NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate
Substrates
5,6,7,8-Tetrahydrofolate
NADP+
Products
H+
Dihydrofolate
NADPH
Enzymes known to
catalyse this reaction
(curated information)
EC Number
in Organism
UniProtKB Link
PubMedID
1.5.1.3
Bos taurus
UniProtKB
2322563
1.5.1.3
Crithidia fasciculata
UniProtKB
4389070
1.5.1.3
Crithidia oncopelti
UniProtKB
4389070
1.5.1.3
Enterococcus faecalis
UniProtKB
-
1.5.1.3
Enterococcus faecalis
UniProtKB
4379861
1.5.1.3
Enterococcus faecium
UniProtKB
2492521
1.5.1.3
Escherichia coli
UniProtKB
11560482
1.5.1.3
Escherichia coli
UniProtKB
12501195
1.5.1.3
Escherichia coli
UniProtKB
14617668
1.5.1.3
Escherichia coli
UniProtKB
15333636
1.5.1.3
Escherichia coli
UniProtKB
15333637
1.5.1.3
Escherichia coli
UniProtKB
15740745
1.5.1.3
Escherichia coli
UniProtKB
1932013
1.5.1.3
Escherichia coli
UniProtKB
1993166
1.5.1.3
Escherichia coli
UniProtKB
2492521
1.5.1.3
Escherichia coli
UniProtKB
3463995
1.5.1.3
Escherichia coli
UniProtKB
8226776
1.5.1.3
Escherichia coli
UniProtKB
8910413
1.5.1.3
Escherichia coli
UniProtKB
9719595
1.5.1.3
Gallus gallus
UniProtKB
2492521
1.5.1.3
Geobacillus stearothermophilus
UniProtKB
16114879
1.5.1.3
Homo sapiens
UniProtKB
19196009
1.5.1.3
Homo sapiens
UniProtKB
19478082
1.5.1.3
Homo sapiens
UniProtKB
2124504
1.5.1.3
Homo sapiens
UniProtKB
2492521
1.5.1.3
Homo sapiens
UniProtKB
4396284
1.5.1.3
Homo sapiens
UniProtKB
7890613
1.5.1.3
Homo sapiens
UniProtKB
9719595
1.5.1.3
Lactobacillus casei
UniProtKB
18551641
1.5.1.3
Lactobacillus casei
UniProtKB
2492521
1.5.1.3
Lactobacillus casei
UniProtKB
2505841
1.5.1.3
Lactobacillus casei
UniProtKB
3922404
1.5.1.3
Lactobacillus casei
UniProtKB
7893701
1.5.1.3
Lactobacillus casei
UniProtKB
9719595
1.5.1.3
Leishmania major
UniProtKB
8144647
1.5.1.3
Leishmania major
UniProtKB
8812831
1.5.1.3
Leishmania major
UniProtKB
9153248
1.5.1.3
Leishmania major
UniProtKB
9724534
1.5.1.3
Leishmania tarentolae
UniProtKB
9153248
1.5.1.3
Leishmania tropica
UniProtKB
3922404
1.5.1.3
Mus musculus
UniProtKB
2492521
1.5.1.3
Mus musculus
UniProtKB
3045118
1.5.1.3
Mus musculus
UniProtKB
4396284
1.5.1.3
Plasmodium falciparum
UniProtKB
17451822
1.5.1.3
Plasmodium falciparum
UniProtKB
9207187
1.5.1.3
Pneumocystis carinii
UniProtKB
19196009
1.5.1.3
Pneumocystis carinii
UniProtKB
9719595
1.5.1.3
Pneumocystis jiroveci
UniProtKB
19196009
1.5.1.3
Rattus norvegicus
UniProtKB
4396284
1.5.1.3
Rattus norvegicus
UniProtKB
9719595
1.5.1.3
Toxoplasma gondii
UniProtKB
9719595
1.5.1.3
Trypanosoma brucei brucei
UniProtKB
19748480
1.5.1.3
Trypanosoma brucei brucei
UniProtKB
8538681
1.5.1.3
Trypanosoma cruzi
UniProtKB
7969266
1.5.1.3
Trypanosoma cruzi
UniProtKB
8920005
1.5.1.3
unknown prokaryotic organism
UniProtKB
15182183
1.5.1.5
Pisum sativum
UniProtKB
8304211
Pathways
Biosynthesis of cofactors
Folate biosynthesis
Metabolic pathways
One carbon pool by folate
External Links
KEGG-Pathway-ID
map01240
map00790
map01100
map00670
KEGG-Reaction-ID
R00939
MetaNetX-Reaction-ID
MNXR97401
Rhea-Reaction-ID
15009
15010
15011
15012
Reactome-Reaction-ID
R-CFA-197972
R-MMU-197972
R-SPO-197972
R-TGU-197972
R-GGA-197972
R-RNO-197972
R-HSA-197972
R-SSC-197972
R-DDI-197972
R-DRE-197972
R-XTR-197972
R-CEL-197972
R-DME-197972
R-BTA-197972
R-SCE-197972
MetaCyc-Reaction-ID
RXN-19329
View all entries for reaction NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate
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