Enzyme Details

EC Classification

2.1.1.45

Enzyme name
(recommended)

thymidylate synthase

Alternative names

5,10-methylenetetrahydrofolate:dUMP C-methyltransferase
dTMP synthase
thymidylate synthetase
methylenetetrahydrofolate:dUMP C-methyltransferase
TMP synthetase

Classification

Transferases

Transferring one-carbon groups

Methyltransferases

Catalyses reactions

5,10-Methylenetetrahydrofolate + dUMP <-> dTMP + Dihydrofolate

ATP + L-Glutamate + Dihydropteroate <-> ADP + Phosphate + Dihydrofolate

2-Mercaptoethanol + E-5-(2-Bromovinyl)-2'-deoxyuridine monophosphate <-> 1-(3-Hydroxy-4-hydroxymethyl-cyclopentyl)-5-[1,4]oxathian-2-yl-1H-pyrimidine-2,4-dione

1,4-Dithiothreitol + 5-Bromo-dUMP <-> dUMP + Oxidized dithiothreitol + Hydrobromic acid

dCMP + 5,10-Methylenetetrahydrofolate <-> Dihydrofolate + 5-Methyldeoxycytidine 5'-phosphate

2 2-Mercaptoethanol + 5-Bromo-dUMP <-> Br- + dUMP + Hydroxyethyl disulfide

5,10-Methylenetetrahydrofolate + 2'-Deoxy-2'-fluorouridine-5'-monophosphate <-> Dihydrofolate + 2'-Deoxy-2'-fluorothymidine-5'-monophosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 2.1.1.45