Enzyme Details

 EC Classification 2.1.2.1
 Enzyme name
(recommended)		 glycine hydroxymethyltransferase
 Alternative names serine aldolase
threonine aldolase
serine hydroxymethylase
5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase
serine hydroxymethyltransferase
allothreonine aldolase
L-serine hydroxymethyltransferase
L-threonine aldolase
serine hydroxymethyltransferase
serine transhydroxymethylase
 Classification
Transferases
Transferring one-carbon groups
Hydroxymethyl-, formyl- and related transferases
 Catalyses reactions
H2O + Glycine + 5,10-Methylenetetrahydrofolate <-> L-Serine + 5,6,7,8-Tetrahydrofolate
Glycine + 4-Trimethylammoniobutanal <-> 3-Hydroxy-N6,N6,N6-trimethyl-L-lysine
L-allo-Threonine <-> Glycine + Acetaldehyde
Pyridoxal phosphate + apo-SHMT1 <-> holo-SHMT1
Pyridoxal phosphate + apo-SHMT2 <-> holo-SHMT2
L-Serine + Tetrahydropteroyl di-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl di-L-glutamate
L-Serine + Tetrahydropteroyl tri-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl tri-L-glutamate
L-Serine + Tetrahydropteroyl tetra-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl tetra-L-glutamate
L-Serine + Tetrahydropteroyl hexa-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl hexa-L-glutamate
L-Serine + Tetrahydropteroyl penta-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl penta-L-glutamate
L-Serine + Tetrahydropteroyl hepta-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl hepta-L-glutamate
L-Serine + Tetrahydropteroyl octa-L-glutamate <-> H2O + Glycine + 5,10-Methylenetetrahydropteroyl octa-L-glutamate
Pyridoxal phosphate + apo-SHMT <-> holo-SHMT
Glycine + holo-SHMT <-> Enzyme-ligand complex
L-Serine + holo-SHMT <-> Enzyme-ligand complex
5,6,7,8-Tetrahydrofolate + D-Serine <-> H2O + Glycine + 5,10-Methylenetetrahydrofolate
D-Serine + holo-SHMT <-> Enzyme-ligand complex
holo-SHMT + Thiosemicarbazide <-> Enzyme-inhibitor complex
DL-beta-Phenylserine <-> Glycine + Benzaldehyde
L-Threonine <-> Glycine + Acetaldehyde
PvSHMT <-> Pyridoxal phosphate + apo-PvSHMT
L-Serine + PvSHMT <-> Enzyme-ligand complex
D-Serine + PvSHMT <-> Enzyme-ligand complex
L-Alanine + PvSHMT <-> Enzyme-ligand complex
5-Formyltetrahydrofolate + holo-SHMT <-> Enzyme-ligand complex
5-Formyltetrahydrofolate + holo-SHMT-Glycine <-> Enzyme-Glycine-5-Formyltetrahydrofolate complex
5-Methyltetrahydrofolate + holo-SHMT <-> Enzyme-ligand complex
5-Methyltetrahydrofolate + holo-SHMT-Glycine <-> Enzyme-Glycine-5-Methyltetrahydrofolate complex
Glycine + holo-SHMT-Tetrahydrofolate <-> Enzyme-Tetrahydrofolate-Glycine complex
L-threo-3-Phenylserine <-> Glycine + Benzaldehyde
Glycine + 5-Formyltetrahydrofolate + SHMT <-> Enzyme-Glycine-5-Formyltetrahydrofolate complex
5-Formyltetrahydrofolate + SHMT <-> Enzyme-ligand complex
Glycine + SHMT <-> Enzyme-ligand complex
 External links Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop


View all entries for EC Class: 2.1.2.1



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