Enzyme Details

EC Classification

3.5.4.16

Enzyme name
(recommended)

GTP cyclohydrolase I

Alternative names

GTP 7,8-8,9-dihydrolase
GTP cyclohydrolase
guanosine triphosphate cyclohydrolase
guanosine triphosphate 8-deformylase
dihydroneopterin triphosphate synthase
GTP 8-formylhydrolase

Classification

Hydrolases

Acting on carbon-nitrogen bonds, other than peptide bonds

In cyclic amidines

Catalyses reactions

H2O + GTP <-> Formamidopyrimidine nucleoside triphosphate

H2O + 7,8-Dihydroneopterin 3'-triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine

H2O + Formamidopyrimidine nucleoside triphosphate <-> Formate + 2,5-Diaminopyrimidine nucleoside triphosphate

2,5-Diaminopyrimidine nucleoside triphosphate <-> 2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)- amino-4-oxopyrimidine

H2O + GTP <-> Formate + 7,8-Dihydroneopterin 3'-triphosphate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 3.5.4.16