Enzyme Details

Enzyme (Recommended) Name	tryptophan 5-monooxygenase
Alternative names	L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating) L-tryptophan hydroxylase indoleacetic acid-5-hydroxylase tryptophan 5-hydroxylase tryptophan hydroxylase
EC Classification	1.14.16.4
Classification	Oxidoreductases Acting on paired donors with incorporation of molecular oxygen With reduced pteridine as one donor, and incorporation of one atom of oxygen
Catalyses reactions	L-Phenylalanine + O2 + Tetrahydrobiopterin <-> H2O + L-Tyrosine + 6,7-Dihydrobiopterin L-Tryptophan + O2 + Tetrahydrobiopterin <-> H2O + 6,7-Dihydrobiopterin + 5-Hydroxy-L-tryptophan L-Phenylalanine + O2 + 6-Methyltetrahydropterin <-> H2O + L-Tyrosine + 6-Methyldihydropterin L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin L-Tryptophan + O2 + 6-Methyltetrahydropterin <-> H2O + 5-Hydroxytryptophan + 6-Methyldihydropterin L-Tryptophan + O2 + 6-Methyltetrahydropterin <-> H2O + 5-Hydroxytryptophan + 4-Hydroxy-6-methyltetrahydropterin L-Tryptophan + O2 + 6,7-Dimethyl tetrahydropterin <-> Unknown + H2O + 5-Hydroxytryptophan
External links	Expasy KEGG IntEnz (EBI) IUBMB Reactome HepatoSys
	View all entries for EC Class 1.14.16.4