Reaction Details

Stochiometric Equation L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin
Substrates
O2
Tetrahydrobiopterin
L-Tryptophan
Products
5-Hydroxy-L-tryptophan
4a-Hydroxytetrahydrobiopterin
Enzymes known to catalyse this reaction (curated information)
EC Numberin OrganismUniProt LinkPubMedID
1.14.16.1 Homo sapiens UniProt 9434741
1.14.16.1 Rattus norvegicus UniProt 7407194
1.14.16.4 Homo sapiens UniProt 16581181
1.14.16.4 Homo sapiens UniProt 17181551
1.14.16.4 Homo sapiens UniProt 17539919
1.14.16.4 Homo sapiens UniProt 17905754
1.14.16.4 Homo sapiens UniProt 17973628
1.14.16.4 Homo sapiens UniProt 19816759
Pathways Folate biosynthesis
Metabolic pathways
Phenylalanine metabolism


View all entries for reaction L-Tryptophan + O2 + Tetrahydrobiopterin <-> 5-Hydroxy-L-tryptophan + 4a-Hydroxytetrahydrobiopterin