Enzyme Details

Enzyme (Recommended) Name dihydrofolate reductase
Alternative names 5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
tetrahydrofolate dehydrogenase
DHFR
pteridine reductase:dihydrofolate reductase
dihydrofolate reductase:thymidylate synthase
thymidylate synthetase-dihydrofolate reductase
folic acid reductase
folic reductase
dihydrofolic acid reductase
dihydrofolic reductase
7,8-dihydrofolate reductase
NADPH-dihydrofolate reductase
EC Classification 1.5.1.3
Classification
Oxidoreductases
Acting on the CH-NH group of donors
With NAD(+) or NADP(+) as acceptor
Catalyses reactions
NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Dihydrofolate
NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Folate
2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate
NAD+ + Dihydrofolate <-> NADH + H+ + Folate
NADP+ + Dihydrofolate <-> H+ + NADPH + Folate
H+ + NADPH + 7,8-Dihydropteroylpentaglutamate <-> NADP+ + 5,6,7,8-Tetrahydropteroylpentaglutamate
H+ + NADPH + 7,8-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin
H+ + NADPH + Dihydropteroyltriglutamate <-> NADP+ + 5,6,7,8-Tetrahydropteroyltriglutamate
External links Expasy
KEGG
IntEnz (EBI)
IUBMB
Reactome
HepatoSys


View all entries for EC Class 1.5.1.3