Reaction Details

Stochiometric Equation 2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate
Substrates
5,6,7,8-Tetrahydrofolate
NADP+
Products
Folate
NADPH
H+
Enzymes known to catalyse this reaction (curated information)
EC Numberin OrganismUniProt LinkPubMedID
1.5.1.3 Escherichia coli UniProt 12559923
1.5.1.3 Lactobacillus casei UniProt 7893701
1.5.1.3 Leishmania major UniProt 9153248
1.5.1.3 Leishmania tarentolae UniProt 9153248
1.5.1.3 Mus musculus UniProt 6882460
1.5.1.33 Leishmania major UniProt 9521731
Pathways Biosynthesis of cofactors
Folate biosynthesis
Metabolic pathways
One carbon pool by folate


View all entries for reaction 2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate