| Enzyme (Recommended) Name |
3-methyl-2-oxobutanoate hydroxymethyltransferase |
| Alternative names |
5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase
alpha-ketoisovalerate hydroxymethyltransferase
dehydropantoate hydroxymethyltransferase
ketopantoate hydroxymethyltransferase
oxopantoate hydroxymethyltransferase
5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase
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| EC Classification |
2.1.2.11
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| Classification |
| Transferases |
| Transferring one-carbon groups |
| Hydroxymethyl-, formyl- and related transferases |
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| Catalyses reactions
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| H2O + 5,10-Methylenetetrahydrofolate + alpha-Ketovaline <-> 5,6,7,8-Tetrahydrofolate + 2-Dehydropantoate |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](2) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](2) |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](3) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](3) |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](4) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](4) |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](5) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](5) |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](6) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](6) |
| 2-Dehydropantoate + Tetrahydrofolyl-[Glu](7) <-> H2O + alpha-Ketovaline + 5,10-Methylenetetrahydrofolyl-[Glu](7) |
| H2O + 5,10-Methylenetetrahydrofolate + 2-Oxobutyrate <-> 5,6,7,8-Tetrahydrofolate + 4-Hydroxy-3-methyl-2-oxobutanoic acid |
| H2O + 5,10-Methylenetetrahydrofolate + 2-Oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-Hydroxymethyl-2-oxopentanoic acid |
| H2O + 5,10-Methylenetetrahydrofolate + 3-Methyl-2-oxopentanoate <-> 5,6,7,8-Tetrahydrofolate + 3-(Hydroxymethyl)-3-methyl-2-oxopentanoic acid |
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| External links
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Expasy
KEGG
IntEnz (EBI)
IUBMB
Reactome
HepatoSys
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View all entries for EC Class 2.1.2.11
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