Pathway Details

Recommended name

Porphyrin and chlorophyll metabolism

Alternative names

Reactions

NADP+ + Precorrin 6Y <-> H+ + NADPH + Precorrin 6X

Cytochrome c <-> Heme + Apocytochrome c

Acceptor + Coproporphyrinogen I <-> 6 H+ + Reduced acceptor + Coproporphyrin I

NADP+ + Cyanide + Cob(I)alamin <-> H+ + NADPH + Cyanocob(III)alamin

2 ATP + 2 H2O + 2 L-Glutamine + Hydrogenobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Hydrogenobyrinate a,c diamide

S-Adenosyl-L-methionine + Precorrin 4 <-> S-Adenosyl-L-homocysteine + Precorrin 5

Heme <-> Catalase

ATP + Cob(I)yrinate a,c diamide <-> Triphosphate + Adenosyl cobyrinate a,c diamide

ATP + Cob(I)yrinate a,c diamide <-> Phosphate + Diphosphate + Adenosyl cobyrinate a,c diamide

O2 + 2 I-Urobilinogen <-> 2 H2O + 2 I-Urobilin

3 O2 + 2 Protoporphyrinogen IX <-> 6 H2O + 2 Protoporphyrin

4 H+ + I-Urobilinogen <-> L-Urobilinogen

L-Threonine <-> L-Threonine O-3-phosphate

Acceptor + Uroporphyrinogen III <-> 6 H+ + Reduced acceptor + Uroporphyrin III

H+ + NADPH + O2 + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H2O + NADP+ + Divinylprotochlorophyllide

O2 + Hemoglobin <-> Oxyhemoglobin

NADP+ + Divinyl chlorophyllide a <-> H+ + NADPH + Divinylprotochlorophyllide

H2O + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole <-> Phosphate + alpha-Ribazole

(R)-1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> H2O + Adenosyl cobinamide

ATP + Cob(I)alamin <-> Triphosphate + Coenzyme B12

Reduced acceptor + Uroporphyrinogen I <-> 6 H+ + Acceptor + Uroporphyrin I

ATP + (R)-1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide

Oxidized ferredoxin + (3Z)-Phytochromobilin <-> Reduced ferredoxin + Biliverdin

NAD+ + 2 Cob(I)alamin <-> NADH + H+ + 2 Cob(II)alamin

ATP + Adenosyl cobinamide <-> ADP + Adenosyl cobinamide phosphate

Heme <-> Heme O

NAD+ + Bilirubin <-> NADH + H+ + Biliverdin

2 UDPglucuronate + Bilirubin <-> 2 UDP + Bilirubin beta-diglucuronide

S-Adenosyl-L-methionine + Cobalt-precorrin 4 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 5

NAD+ + Transferrin[Fe(II)]2 <-> NADH + H+ + Transferrin[Fe(III)]2

2 H+ + Acceptor + (3Z)-Phycocyanobilin <-> 2 H+ + Reduced acceptor + (3Z)-Phycoerythrobilin

S-Adenosyl-L-methionine + Cobalt-precorrin 3 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 4

Transferrin[Fe(II)]2 <-> Apotransferrin + Iron

Transferrin[Fe(III)]2 <-> Apoferritin + Iron

H2O + Chlorophyll b <-> Phytol + Chlorophyllide b

Pyruvate + 5-Aminolevulinate <-> L-Alanine + 4,5-Dioxopentanoate

Nicotinate D-ribonucleotide + Dimethylbenzimidazole <-> Nicotinate + N1-(5-Phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole

Uroporphyrinogen III <-> 4 CO2 + Coproporphyrinogen III

O2 + Precorrin 3A <-> Precorrin 3B

Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Chlorophyll a

2 S-Adenosyl-L-methionine + Precorrin 6Y <-> CO2 + 2 S-Adenosyl-L-homocysteine + Precorrin 8X

3 O2 + Coproporphyrinogen III <-> 3 H2O2 + Coproporphyrin III

2 ATP + 2 H2O + 2 L-Glutamine + Cobyrinate <-> 2 ADP + 2 Phosphate + 2 L-Glutamate + Cob(II)yrinate a,c diamide

H2O + S-Adenosyl-L-methionine + Cobalt-precorrin 5 <-> S-Adenosyl-L-homocysteine + Acetaldehyde + Cobalt-precorrin 6

3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe3+ + Carbon monoxide + Biliverdin + Globin

ATP + H2O + Mg2+ + Protoporphyrin <-> ADP + Phosphate + 2 H+ + Magnesium protoporphyrin

Acceptor + Coproporphyrinogen III <-> 6 H+ + Reduced acceptor + Coproporphyrin III

Glycine + Succinyl-CoA <-> Coenzyme A + CO2 + 5-Aminolevulinate

H2O + Chlorophyll a <-> Phytol + Chlorophyllide a

H+ + NADPH + O2 + 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H2O + NADP+ + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester

NADP+ + Chlorophyllide a <-> H+ + NADPH + Protochlorophyllide

13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H+ + Divinylprotochlorophyllide

NADP+ + Bilirubin <-> H+ + NADPH + Biliverdin

L-Threonine O-3-phosphate <-> CO2 + D-1-Aminopropan-2-ol O-phosphate

S-Adenosyl-L-methionine + Precorrin 3B <-> S-Adenosyl-L-homocysteine + Precorrin 4

H2O + 4 Porphobilinogen <-> 4 NH3 + Hydroxymethylbilane

Holocytochrome c <-> Heme + Apocytochrome c

Hydroxymethylbilane <-> H2O + Uroporphyrinogen I

NAD+ + 2 H2O + 2 Cob(II)alamin <-> NADH + H+ + 2 Aquacob(III)alamin

2 H+ + Divinylprotochlorophyllide <-> Protochlorophyllide

H+ + NADPH + L-Glutamyl-tRNA(Glu) <-> NADP+ + tRNA(Glu) + (S)-4-Amino-5-oxopentanoate

5-Aminolevulinate <-> (S)-4-Amino-5-oxopentanoate

4 ATP + 4 L-Glutamine + Adenosyl cobyrinate a,c diamide <-> 4 ADP + 4 Phosphate + 4 L-Glutamate + Adenosyl cobyrinate hexaamide

Transferrin[Fe(III)]2 <-> Fe3+ + Apoferritin

2 H+ + 2 Reduced ferredoxin + Red chlorophyll catabolite <-> 2 Oxidized ferredoxin + Primary fluorescent chlorophyll catabolite

NAD+ + Precorrin 2 <-> NADH + H+ + Sirohydrochlorin

Reduced ferredoxin + Biliverdin <-> Oxidized ferredoxin + 15,16-Dihydrobiliverdin

ATP + D-1-Aminopropan-2-ol O-phosphate + Adenosyl cobyrinate hexaamide <-> ADP + Phosphate + Adenosyl cobinamide phosphate

Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Mg2+ + Bacterio-pheophytins

2 S-Adenosyl-L-methionine + Uroporphyrinogen III <-> 2 S-Adenosyl-L-homocysteine + Precorrin 2

H+ + NADPH + 2 Aquacob(III)alamin <-> 2 H2O + NADP+ + 2 Cob(II)alamin

1-Aminopropan-2-ol + Adenosyl cobyrinate hexaamide <-> Adenosyl cobinamide

O2 + 2 L-Urobilinogen <-> 2 H2O + 2 L-Urobilin

ATP + Cobinamide <-> Triphosphate + Adenosyl cobinamide

3 O2 + 3 Reduced acceptor + Heme <-> 3 H2O + Fe2+ + Carbon monoxide + 3 Acceptor + Biliverdin

H+ + NADPH + L-Glutamyl-tRNA(Glu) <-> H2O + NADP+ + tRNA(Glu) + (S)-4-Amino-5-oxopentanoate

S-Adenosyl-L-methionine + Precorrin 2 <-> S-Adenosyl-L-homocysteine + Precorrin 3A

H2O + Magnesium protoporphyrin monomethyl ester <-> 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

S-Adenosyl-L-methionine + Cobalt-precorrin 2 <-> S-Adenosyl-L-homocysteine + Cobalt-precorrin 3

GMP + Coenzyme B12 <-> Adenosine-GDP-cobinamide + alpha-Ribazole

Hydroxymethylbilane <-> H2O + Uroporphyrinogen III

Ni2+ + Precorrin 2 <-> Coenzyme F430

GTP + Adenosyl cobinamide <-> GDP + Adenosyl cobinamide phosphate

Heme O <-> Heme A

Reduced ferredoxin + Biliverdin <-> Oxidized ferredoxin + (3Z)-Phycocyanobilin

2 S-Adenosyl-L-methionine + Coproporphyrinogen III <-> 2 L-Methionine + 2 CO2 + 2 5'-Deoxyadenosine + Protoporphyrinogen IX

NADH + H+ + Cob(II)yrinate a,c diamide <-> NAD+ + Cob(I)yrinate a,c diamide

S-Adenosyl-L-homocysteine + Acetate + Precorrin 6X <-> H2O + S-Adenosyl-L-methionine + Precorrin 5

4 H+ + O2 + 4 Fe2+ <-> 2 H2O + 4 Fe3+

3 O2 + FADH2 + Hemoglobin <-> 3 H2O + FAD + Fe2+ + Carbon monoxide + Biliverdin + Globin

2 H+ + D-Urobilinogen <-> I-Urobilinogen

Divinylchlorophyll a <-> Chlorophyll a

Fe2+ + Protoporphyrin <-> 2 H+ + Heme

Divinyl chlorophyllide a <-> Divinylchlorophyll a

GTP + Adenosyl cobinamide phosphate <-> Diphosphate + Adenosine-GDP-cobinamide

Co2+ + ATP + Hydrogenobyrinate a,c diamide <-> ADP + Phosphate + Cob(II)yrinate a,c diamide

Cobalt-precorrin 8 <-> Cobyrinate

Phytyl diphosphate + Chlorophyllide a <-> Diphosphate + Bacterio-chlorophylls

Reduced ferredoxin + 15,16-Dihydrobiliverdin <-> Oxidized ferredoxin + (3Z)-Phycoerythrobilin

2 S-Adenosyl-L-methionine + Cobalt-dihydro-precorrin 6 <-> CO2 + 2 S-Adenosyl-L-homocysteine + Cobalt-precorrin 8

ATP + Protochlorophyllide <-> ADP + Phosphate + Chlorophyllide a

Myoglobin <-> Heme + Globin

O2 + 2 Bilirubin <-> 2 H2O + 2 Biliverdin

Hemoglobin <-> Heme + Globin

Transferrin[Fe(II)]2 <-> Fe2+ + Apotransferrin

O2 + 2 D-Urobilinogen <-> 2 H2O + 2 D-Urobilin

ATP + L-Glutamate + tRNA(Glu) <-> Diphosphate + AMP + L-Glutamyl-tRNA(Glu)

2 5-Aminolevulinate <-> 2 H2O + Porphobilinogen

2 H+ + Siroheme <-> Fe2+ + Sirohydrochlorin

Heme <-> Peroxidase

Uroporphyrinogen I <-> 4 CO2 + Coproporphyrinogen I

13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester <-> 2 H+ + 13(1)-Oxo-magnesium-protoporphyrin IX 13-monomethyl ester

H+ + NADPH + O2 + Magnesium protoporphyrin monomethyl ester <-> H2O + NADP+ + 13(1)-Hydroxy-magnesium-protoporphyrin IX 13-monomethyl ester

H+ + NADPH + Divinyl chlorophyllide a <-> NADP+ + Chlorophyllide a

Acceptor + (3Z)-Phycocyanobilin <-> 2 H+ + Reduced acceptor + (3Z)-Phytochromobilin

4 ATP + 4 H2O + 4 L-Glutamine + Adenosyl cobyrinate a,c diamide <-> 4 ADP + 4 Phosphate + 4 L-Glutamate + Adenosyl cobyrinate hexaamide

Heme <-> Cytochrome a

6 H+ + 2 H2O + Bilirubin beta-diglucuronide <-> 2 D-Glucuronate + D-Urobilinogen

Co2+ + Sirohydrochlorin <-> Cobalt-precorrin 2

O2 + Coproporphyrinogen III <-> 2 H2O + 2 CO2 + Protoporphyrinogen IX

S-Adenosyl-L-methionine + Magnesium protoporphyrin <-> S-Adenosyl-L-homocysteine + Magnesium protoporphyrin monomethyl ester

Precorrin 8X <-> Hydrogenobyrinate

H+ + NADPH + Cobalt-precorrin 6 <-> NADP+ + Cobalt-dihydro-precorrin 6

Classification

Metabolism of Cofactors and Vitamins