Pathway Details
Recommended name
Valine, leucine and isoleucine biosynthesis
Alternative names
Reactions
Coenzyme A + 2-Isopropylmalate <-> H2O + Acetyl-CoA + alpha-Ketovaline
CO2 + (S)-2-Acetolactate <-> 2 Pyruvate
L-Threonine <-> NH3 + 2-Oxobutyrate
NAD+ + H2O + L-Leucine <-> NADH + H+ + NH3 + 4-Methyl-2-oxopentanoate
L-Leucine + 2-Oxoglutarate <-> L-Glutamate + 4-Methyl-2-oxopentanoate
2,3-Dihydroxy-3-methylbutanoate <-> H2O + alpha-Ketovaline
L-Valine + 2-Oxoglutarate <-> L-Glutamate + alpha-Ketovaline
Pyruvate + L-Valine <-> L-Alanine + alpha-Ketovaline
NAD+ + H2O + L-Valine <-> NADH + H+ + NH3 + alpha-Ketovaline
CO2 + 4-Methyl-2-oxopentanoate <-> 3-Carboxy-4-methyl-2-oxopentanoate
L-Isoleucine + 2-Oxoglutarate <-> L-Glutamate + 3-Methyl-2-oxopentanoate
D-Citramalate <-> H2O + 2-Methylmaleate
H2O + 2-Methylmaleate <-> D-erythro-3-Methylmalate
2-Isopropylmalate <-> H2O + 2-Isopropylmaleate
3-Isopropylmalate <-> H2O + 2-Isopropylmaleate
NAD+ + 3-Isopropylmalate <-> NADH + H+ + 3-Carboxy-4-methyl-2-oxopentanoate
(R)-2,3-Dihydroxy-3-methylbutanoate <-> H2O + alpha-Ketovaline
CO2 + 2-Acetolactate <-> 2 Pyruvate
Pyruvate + 2-Oxobutyrate <-> CO2 + (S)-2-Aceto-2-hydroxybutanoate
NAD+ + H2O + L-Isoleucine <-> NADH + H+ + NH3 + 3-Methyl-2-oxopentanoate
NAD+ + H2O + L-Isoleucine <-> NADH + H+ + NH3 + (S)-3-Methyl-2-oxopentanoate
(S)-2-Acetolactate <-> 3-Hydroxy-3-methyl-2-oxobutanoate
NADP+ + (R)-2,3-Dihydroxy-3-methylbutanoate <-> H+ + NADPH + 3-Hydroxy-3-methyl-2-oxobutanoate
Pyruvate + H2O + Acetyl-CoA <-> Coenzyme A + D-Citramalate
L-Isoleucine + 2-Oxoglutarate <-> L-Glutamate + (S)-3-Methyl-2-oxopentanoate
NADP+ + (R)-2,3-Dihydroxy-3-methylpentanoate <-> H+ + NADPH + (R)-3-Hydroxy-3-methyl-2-oxopentanoate
(S)-2-Aceto-2-hydroxybutanoate <-> (R)-3-Hydroxy-3-methyl-2-oxopentanoate
(R)-2,3-Dihydroxy-3-methylpentanoate <-> H2O + (S)-3-Methyl-2-oxopentanoate
Classification
Amino Acid Metabolism
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