Reaction Details

Reaction ID

1350

Stochiometric Equation

NAD+ + H2O + L-Leucine <-> NADH + H+ + NH3 + 4-Methyl-2-oxopentanoate

Substrates

NAD+

H2O

L-Leucine

Products

NADH

NH3

4-Methyl-2-oxopentanoate

H+

Enzymes known to
catalyse this reaction
(curated information)

EC Number	in Organism	UniProtKB Link	PubMedID
1.4.1.20	Bacillus badius	UniProtKB	19270409
1.4.1.20	Lysinibacillus sphaericus	UniProtKB	12234181
1.4.1.20	Lysinibacillus sphaericus	UniProtKB	14622249
1.4.1.20	Lysinibacillus sphaericus	UniProtKB	19270409
1.4.1.20	Thermoactinomyces intermedius	UniProtKB	8407879
1.4.1.8	Streptomyces fradiae	UniProtKB	3269392

Pathways

Biosynthesis of secondary metabolites
Metabolic pathways
Nitrogen metabolism
Valine, leucine and isoleucine biosynthesis
Valine, leucine and isoleucine degradation

External Links

KEGG-Pathway-ID

map01110
map01100
map00910
map00290
map00280

KEGG-Reaction-ID

R01088

MetaNetX-Reaction-ID

MNXR101096

Rhea-Reaction-ID

12220 12223 12221 12222

MetaCyc-Reaction-ID

LEUCINE-DEHYDROGENASE-RXN

View all entries for reaction NAD+ + H2O + L-Leucine <-> NADH + H+ + NH3 + 4-Methyl-2-oxopentanoate