Pathway Details

Recommended name

Citrate cycle (TCA cycle)

Alternative names

Krebs cycle

TCA cycle

Citric acid cycle

Reactions

NAD+ + Dihydrolipoamide <-> NADH + H+ + Lipoamide

Pyruvate + ATP + Hydrogencarbonate <-> ADP + Phosphate + Oxaloacetate

GTP + Oxaloacetate <-> Phosphoenolpyruvate + CO2 + GDP

NAD+ + L-Malate <-> NADH + H+ + Oxaloacetate

NAD+ + L-Malate <-> Pyruvate + NADH + H+ + CO2

NADP+ + L-Malate <-> Pyruvate + H+ + NADPH + CO2

ATP + Oxaloacetate <-> Phosphoenolpyruvate + ADP + CO2

Oxalosuccinate <-> CO2 + 2-Oxoglutarate

NADP+ + Isocitrate <-> H+ + NADPH + Oxalosuccinate

Thiamine diphosphate + 2-Oxoglutarate <-> CO2 + 3-Carboxy-1-hydroxypropyl-ThPP

Lipoamide + 3-Carboxy-1-hydroxypropyl-ThPP <-> Thiamine diphosphate + S-Succinyldihydrolipoamide

Dihydrolipoamide + Succinyl-CoA <-> Coenzyme A + S-Succinyldihydrolipoamide

L-Malate <-> H2O + Fumarate

Succinate + Acceptor <-> Fumarate + Reduced acceptor

Succinate + Ubiquinone <-> Fumarate + Ubiquinol

Coenzyme A + GTP + Succinate <-> Phosphate + GDP + Succinyl-CoA

ATP + Coenzyme A + Succinate <-> ADP + Phosphate + Succinyl-CoA

H2O + Succinyl-CoA <-> Coenzyme A + Succinate

Citrate <-> Acetate + Oxaloacetate

(3S)-Citryl-CoA <-> Acetyl-CoA + Oxaloacetate

Acetyl-CoA + Citrate <-> Acetate + (3S)-Citryl-CoA

ATP + Coenzyme A + Citrate <-> ADP + Phosphate + (3S)-Citryl-CoA

ATP + Coenzyme A + Citrate <-> ADP + Phosphate + Acetyl-CoA + Oxaloacetate

Coenzyme A + Citrate <-> H2O + Acetyl-CoA + Oxaloacetate

Citrate <-> H2O + cis-Aconitate

NADP+ + Isocitrate <-> H+ + NADPH + CO2 + 2-Oxoglutarate

NAD+ + Isocitrate <-> NADH + H+ + CO2 + 2-Oxoglutarate

CO2 + Succinyl-CoA + Reduced ferredoxin <-> Coenzyme A + 2-Oxoglutarate + Oxidized ferredoxin

Citrate <-> Isocitrate

Isocitrate <-> H2O + cis-Aconitate

ITP + Oxaloacetate <-> Phosphoenolpyruvate + CO2 + IDP

Coenzyme A + ITP + Succinate <-> Phosphate + IDP + Succinyl-CoA

L-Malate + Acceptor <-> Oxaloacetate + Reduced acceptor

CO2 + 2-(alpha-Hydroxyethyl)thiamine diphosphate <-> Pyruvate + Thiamine diphosphate

Acetate + Succinyl-CoA <-> Acetyl-CoA + Succinate

Classification

Carbohydrate Metabolism

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