Reaction Details

Reaction ID

1443

Stochiometric Equation

NAD+ + Coenzyme A + alpha-Ketovaline <-> NADH + H+ + CO2 + 2-Methylpropanoyl-CoA

Substrates

Coenzyme A

NAD+

alpha-Ketovaline

Products

NADH

CO2

2-Methylpropanoyl-CoA

H+

Enzymes known to
catalyse this reaction
(curated information)

EC Number	in Organism	UniProtKB Link	PubMedID
1.2.1.25	Homo sapiens	UniProtKB	15166214
1.2.4.4	Homo sapiens	UniProtKB	15576032
1.2.4.4	Rattus norvegicus	UniProtKB	8034607
1.2.4.4	Rattus norvegicus	UniProtKB	8537366
2.7.11.4	Homo sapiens	UniProtKB	12902323
Complex: 1.2.4.4 / 2.3.1.168	Bos taurus	UniProtKB	283398
Complex: 1.2.4.4 / 2.3.1.168	Oryctolagus cuniculus	UniProtKB	7142221
Complex: 1.2.4.4 / 2.3.1.168	Rattus norvegicus	UniProtKB	658436
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4	Homo sapiens	UniProtKB	3593587
Complex: 1.2.4.4 / 2.3.1.168 / 1.8.1.4	Rattus norvegicus	UniProtKB	3571202

Pathways

Valine, leucine and isoleucine degradation

External Links

KEGG-Pathway-ID

map00280

KEGG-Reaction-ID

R01210

MetaNetX-Reaction-ID

MNXR102173

Rhea-Reaction-ID

14000 13997 13999 13998

MetaCyc-Reaction-ID

1.2.1.25-RXN