Enzyme Details

EC Classification

1.5.1.3

Enzyme name
(recommended)

dihydrofolate reductase

Alternative names

5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase
tetrahydrofolate dehydrogenase
DHFR
pteridine reductase:dihydrofolate reductase
dihydrofolate reductase:thymidylate synthase
thymidylate synthetase-dihydrofolate reductase
folic acid reductase
folic reductase
dihydrofolic acid reductase
dihydrofolic reductase
7,8-dihydrofolate reductase
NADPH-dihydrofolate reductase

Classification

Oxidoreductases

Acting on the CH-NH group of donors

With NAD(+) or NADP(+) as acceptor

Catalyses reactions

NADP+ + 5,6,7,8-Tetrahydrofolate <-> H+ + NADPH + Dihydrofolate

NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Dihydrofolate

NAD+ + 5,6,7,8-Tetrahydrofolate <-> NADH + H+ + Folate

2 NADP+ + 5,6,7,8-Tetrahydrofolate <-> 2 H+ + 2 NADPH + Folate

NAD+ + Dihydrofolate <-> NADH + H+ + Folate

NADP+ + Dihydrofolate <-> H+ + NADPH + Folate

H+ + NADPH + 7,8-Dihydropteroylpentaglutamate <-> NADP+ + 5,6,7,8-Tetrahydropteroylpentaglutamate

H+ + NADPH + 7,8-Dihydrobiopterin <-> NADP+ + Tetrahydrobiopterin

H+ + NADPH + Dihydropteroyltriglutamate <-> NADP+ + 5,6,7,8-Tetrahydropteroyltriglutamate

External links

Expasy
KEGG
BRENDA
IntEnz (EBI)
IUBMB
Reactome
MetaCrop

View all entries for EC Class: 1.5.1.3